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- Title
Chromosomal Analysis In Couples With Recurrent Spontaneous Abortion: A Case Control Study.
- Authors
Dutta, Malamoni; Mahanta, Jagadish; Das, Gokul Chandra; Rai, Avdesh Kumar
- Abstract
Background: Normal expected outcome of a couple is birth of a healthy child after completion of the period of pregnancy. About 50% of pregnancies end in fetal loss as abortion. Lower implantation and higher spontaneous abortion rate are closely associated with the chromosomal abnormalities of the parents. It has been recommended that the standard investigation of such cases should include karyotyping of both the parents for chromosomal aberrations. The aim of the study was to find out whether any specific chromosomal abnormalities exist in couples with recurrent spontaneous abortion. Method: 75 couples with history of recurrent spontaneous abortion as well as 75 fertile couples as control were investigated for chromosomal aberrations. Statistical analysis (Chi square test) was done to find out the association of recurrent spontaneous abortion with chromosomal abnormalities of the parents. Result: Out of 75 couples (150 subjects) with recurrent spontaneous abortion, 10 subjects(6.7%) were found to be having abnormal karyotypes. The statistical analysis (p<0.05) signifies that chromosomal abnormalities of the parents are associated with recurrent spontaneous abortion. Conclusion: Recurrent spontaneous abortion continues to be a challenging reproductive problem for the clinician. Therefore, identifying a cytogenetic cause may be of great significance for the management of such cases.
- Subjects
CHROMOSOME analysis; RECURRENT miscarriage; KARYOTYPES
- Publication
National Journal of Integrated Research in Medicine, 2018, Vol 9, Issue 4, p25
- ISSN
2230-9969
- Publication type
Article