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- Title
Expression of CD44 and SALL4 in Leukoplakia and Oral Squamous Cell Carcinoma.
- Authors
Sahoo, Pravudeva; Kumar, Harish; Panda, Abikshyeet; Dash, Kailash Chandra; Bhuyian, Lipsa; Raghuvanshi, Malvika; Panda, Baisali
- Abstract
CD44 and SALL4 are markers of stemness and expressed in cancer stem cells (CSCs). Their deregulated expression was seen in various tumors and has been correlated with clinical severity. We evaluated immunohistochemical expression of CD44 and SALL4 in leukoplakia and oral squamous cell carcinoma (OSCC). CD44 was expressed in all the cases of leukoplakia and Its expression correlated with severity of the dysplasia in leukoplakia but varied with differentiation in OSCC. SALL4 did not express in leukoplakia. Its expression was varied in OSCC cases. We opine that CD44 expression is consistent with the progression of dysplasia in leukoplakia and differentiation in OSCC.
- Subjects
ORAL leukoplakia; SQUAMOUS cell carcinoma; CD44 antigen; DYSPLASIA; CANCER stem cells; LEUKOPLAKIA
- Publication
Journal of Pharmacy & Bioallied Sciences, 2024, Vol 16, pS1761
- ISSN
0976-4879
- Publication type
Article
- DOI
10.4103/jpbs.jpbs_1178_23