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- Title
Von Willebrand disease - the ' Dos' and ' Don'ts' in surgery.
- Authors
Miesbach, Wolfgang; Berntorp, Erik
- Abstract
Von Willebrand disease ( VWD) is the most common genetic bleeding disorder. VWD is caused by a deficiency or dysfunction of von Willebrand factor ( VWF), a plasma protein that mediates the initial adhesion of platelets at sites of vascular injury and binds and stabilises coagulation factor VIII ( FVIII) in the blood. Prophylaxis of surgical bleeding in patients with VWD requires consideration of the individual situation, including the type of procedure and the bleeding rate, before decisions about treatment type, dose, duration and adjunctive therapy with antifibrinolytics or antithrombotic prophylaxis can be made. Although desmopressin ( DDAVP)-stimulated release of endogenous VWD is an effective treatment strategy in many patients, plasma concentrates containing VWF are the preferred option for most patients undergoing surgical procedures. Recommendations for the management of surgery in patients with VWD are summarised, including the severity of VWD and the type of the surgical procedure.
- Subjects
VON Willebrand disease treatment; OPERATIVE surgery; GENETIC disorders; BLOOD proteins; DESMOPRESSIN; BLOOD coagulation factor VIII
- Publication
European Journal of Haematology, 2017, Vol 98, Issue 2, p121
- ISSN
0902-4441
- Publication type
Article
- DOI
10.1111/ejh.12809