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- Title
IMMUNOHISTOCHEMICAL EXPRESSION OF VEGF IN HEPATOCELLULAR CARCINOMA AND SURROUNDING LIVER TISSUE.
- Authors
BASA, Norina; CORNIANU, Marioara; LAZĂR, Elena; DEMA, Alis; TĂBAN, Sorina; LAZĂR, Daniela; LĂZUREANU, Codruţa; FAUR, Alexandra; TUDOR, A.; MOŞ, Liana; PRIBAC, George Ciprian
- Abstract
Introduction: Angiogenesis is a fundamental process involved in malignant transformation and progression of cancer, in tumor growth and metastasis. VEGF plays an essential role in the angiogenesis of hepatocellular carcinoma (HCC). Method: We evaluated VEGF expression in 16 resected HCCs and in the surrounding liver tissue using the IHC staining method and monoclonal antibody anti-VEGF, clone VG1. The results were statistically analyzed using the Epi Info 6.04 program; we considered as significant the value < 0.05. Results: Positive VEGF expression was observed in 14 (87.7%) of the 16 patients with HCC and in 62.5% of the surrounding liver tissue (cirrhotic or non-cirrhotic), without significant differences between HCC and non-Tumor liver (0.11). Capsular infiltration (p=0.242), vascular invasion (p=0.383) and intrahepatic metastases (p=0.13) were observed more frequently in patients with positive VEGF expression. Conclusions: VEGF expression was higher in HCC than in cirrhotic nodules; our results suggest that VEGF can play an important role in the angiogenesis and prognosis of HCC, as well as in the angiogenesis of liver cirrhosis.
- Publication
Studia Universitatis Vasile Goldis Seria Stiintele Vietii (Life Sciences Series), 2011, Vol 21, Issue 3, p479
- ISSN
1584-2363
- Publication type
Article