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- Title
Sequence Variant in the LPIN1 gene in Patients with Metabolic Syndrome.
- Authors
Vanizor Kural, Birgül; Değer, Orhan; Erem, Cihangir; Balaban Yücesan, Fulya; Barlak, Yaşam; Turan, İbrahim; Aliyazıcıoğlu, Rezzan
- Abstract
Objective: Metabolic syndrome (MetS) is a complex disease characterized by insulin resistance, abdominal obesity, hyperglycemia, hypertension, hypertriglyceridemia and low HDL-cholesterol level. The aim of the study was to evaluate the sequence variations in the LPIN1 gene in MetS. This gene codes lipin-1 protein which functions as Mg-dependent phosphatidic phosphatase enzyme and transcriptional coactivator. Material and Methods: The study groups included 73 MetS (19 M/54 F) and 56 non-MetS (16 M/ 40 F). Sequence variation in exons 2, 4, 5 and 14 of the LPIN1 gene were investigated by DNA sequencing method. Results: c.696 G>C variant (p.S232S) in exon 5 was observed in only one women with MetS. But this variation is not important because of coding same amino acid. Conclusion: Any important sequence variant was not detected in exons 2, 4, 5 and 14 in the LPIN1 gene in MetS.
- Subjects
METABOLIC syndrome; LIPIDS; OBESITY; HYPERGLYCEMIA; HYPERTENSION
- Publication
Turkish Journal of Biochemistry / Turk Biyokimya Dergisi, 2013, Vol 38, Issue 3, p280
- ISSN
0250-4685
- Publication type
Article
- DOI
10.5505/tjb.2013.41033