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- Title
Serum and Urinary Cytokine Homeostasis and Renal Tubular Function in Children with Type 1 Diabetes Mellitus.
- Authors
Myśliwiec, Małgorzata; Balcerska, Anna; Zorena, Katarzyna; Myśliwska, Jolanta; Lipska, Beata S.; Wiśniewski, Piotr; Myśliwski, Andrzej
- Abstract
Aim: To explore the relationships between tumor necrosis factor-alpha (TNFα), interleukin-6 (IL-6) and urinary N-acetyl-beta-D-glucosaminidase (NAG) and the function of renal proximal tubules in children with type 1 diabetes mellitus (DM1). Methods: Fifty-six children with DM1 and 35 healthy controls were analyzed. We measured NAG (A and B isoforms) in urine as well as serum TNFalpha and urinary IL-6. Results: The children with DM1 with microalbuminuria (group A) had significantly higher urinary IL-6 and serum TNFa than the children without microalbuminuria (group B). The diabetic patients with no sign of nephropathy showed significantly higher TNFalpha and NAG and its A and B isoforms in urine compared to the healthy group. Additionally, groups A and B both showed a positive significant correlation between serum TNFalpha and urinary isoform B. Conclusions: From our pilot results it appears that TNFα might be a sensitive marker of damage to the renal proximal tubules occurring prior to microalbuminuria. Conversely, the increase in NAG and its isoform B activity in patients with no clinical sign of diabetic nephropathy may indicate the onset of microalbuminuria.
- Publication
Journal of Pediatric Endocrinology & Metabolism, 2006, Vol 19, Issue 12, p1421
- ISSN
0334-018X
- Publication type
Article
- DOI
10.1515/jpem.2006.19.12.1421