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- Title
Production of polycyclic aromatic hydrocarbon metabolites from a peroxynitrite/iron(III) porphyrin biomimetic model and their mutagenicities.
- Authors
Yunjing Luo; Jing Dai; Rugang Zhong; Yuanbin She; Rui Liu; Huachen Wei
- Abstract
Some polycyclic aromatic hydrocarbons (PAHs) are typical promutagens that require metabolic activation to exhibit their mutagenicities and carcinogenicities. The metabolites of three PAHs, pyrene (PY), fluoranthene (FLU), and benzo[ a]pyrene (B aP), produced from the peroxynitrite/T( p-Cl)PPFeCl(peroxynitrite/(chloride)iron(III)tetrakis( p-chlorophenyl)porphyrin) system, have been identified with high-performance liquid chromatography coupled with electron spray ionization tandem mass spectrometry. The results demonstrated that three major metabolites were the quinone group, OH group, and nitro group. In the Ames test, all three PAH metabolites became mutagenic without using the enzymatic activating system, whereas their parents did not show positive results. Cell transformation assay indicated that 1,3-nitro-B aP and B aP metabolites produced from this biomimetic system have more serious effects in inducing cancer than the B aP parent. Environ. Toxicol. Chem. 2011; 30:723-729. © 2010 SETAC
- Subjects
POLYCYCLIC aromatic hydrocarbons; METABOLITES; BIOMIMETIC chemicals; MUTAGENICITY testing; TANDEM mass spectrometry; HIGH performance liquid chromatography; ENZYME activation; CELL transformation
- Publication
Environmental Toxicology & Chemistry, 2011, Vol 30, Issue 3, p723
- ISSN
0730-7268
- Publication type
Article
- DOI
10.1002/etc.430