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- Title
Synthesis of β-Lapachone, a Potential Anticancer Agent from the Lapacho Tree.
- Authors
Katoh, Takeru; Monma, Hiromitsu; Wakasugi, Jun; Narita, Koichi; Katoh, Tadashi
- Abstract
A pharmaceutically important natural product, β-lapachone, was efficiently synthesized in four steps in 70 % overall yield starting from commercially available 1,4-naphthoquinone. The key step of the synthesis was the direct conversion of 2-prenyl-1,4-naphthoquinone into β-lapachone through an advantageous cyclization/hydration/oxidation cascade process.
- Subjects
ANTINEOPLASTIC agents; CANCER chemotherapy; LAPACHO (Tea); RING formation (Chemistry); CHEMICAL reactions
- Publication
European Journal of Organic Chemistry, 2014, Vol 2014, Issue 32, p7099
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201403064