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- Title
Dual Catalysis in Domino N-Benzylation/Intramolecular C-H Arylation: Regio- and Chemoselective Synthesis of Annelated Nitrogen Heterocycles.
- Authors
Laha, Joydev K.; Dayal, Neetu; Singh, Swati; Bhimpuria, Rohan
- Abstract
A general method has been developed for the synthesis of fused nitrogen heterocycles by using a domino N-benzylation/C-H arylation reaction sequence. The details and yields of the domino process were compared with those of the two-step literature protocol. Fused azaindoles, which are otherwise difficult to obtain, were synthesized by using this process. The unprecedented catalytic role of PPh3 in this N-benzylation is described.
- Subjects
NITROGEN; HETEROCYCLIC compounds; ARYLATION; AZAINDOLES; AZA compounds
- Publication
European Journal of Organic Chemistry, 2014, Vol 2014, Issue 25, p5469
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201402395