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- Title
An Easy Route to N, N-Diarylhydrazines by Cu-Catalyzed Arylation of Pyridine-2-carbaldehyde Hydrazones with Aryl Halides.
- Authors
Wu, Wei; Li, Xin‐Le; Fan, Xin‐Heng; Yang, Lian‐Ming
- Abstract
A copper-catalyzed C-N coupling reaction is described for the preparation of pyridine-2-carbaldehyde N, N-diarylhydrazones by the arylation of N-mono- or -non-substituted hydrazones with aryl bromides/iodides, and the subsequent conversion of the hydrazones into N, N-diarylhydrazines by a transimination process with an aqueous solution of H2NNH2. The reaction features the use of CuI as the catalyst without the need for external ligands. This methodology provides a convenient alternative to the synthesis of structurally diverse N, N-diarylhydrazines from simple, easily accessible precursors.
- Publication
European Journal of Organic Chemistry, 2013, Vol 2013, Issue 5, p862
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201201445