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- Title
The Impact of Hippocampal-Sparing Whole- Brain Radiotherapy on Survival and Cognitive Function in Patients with Brain Metastases.
- Authors
Jiangrong Du; Yufang Liao; Yong Zhang; Boju Yang; Yu Wu; Chaoyuan Liu; Xiuyong Liao
- Abstract
Objective • To explore the effects on cognitive function and survival time of whole-brain intensity-modulated radiotherapy using radiotherapy equipment to protect the hippocampus. Methods • Thirty-six patients with brain metastases treated at Qianjiang Central Hospital were enrolled in this study from January 2019 to September 2022. The patients were randomly divided into 2 groups: 15 patients received hippocampal-protection whole-brain radiotherapy, and 21 patients received conventional whole-brain radiotherapy. The Montreal Cognitive Assessment was used to evaluate the cognitive function of patients before and 24 hours, 2 months, 6 months, and 12 months after radiotherapy. Cognitive dysfunction and survival time were compared between the 2 groups. Results • The overall mean differences in the Montreal Cognitive Assessment scores between the hippocampalprotection group and the conventional whole-brain radiotherapy group were statistically significant at 6 months (P = .006) and 12 months (P = .04) after radiotherapy. The median overall survival was 16 months (95% CI, 11.54- 20.46) for the hippocampal-protection group and 14 months (95% CI, 12.9-15.21) for the conventional wholebrain radiotherapy group (P = .578). The median progression-free survival was 12 months (95% CI, 9.74- 14.26) for the hippocampal-protection group and 9 months (95% CI, 6.60-11.44) for the conventional whole-brain radiotherapy group (P = .494). Conclusion • Whole-brain radiotherapy for protecting the hippocampus can delay cognitive dysfunction in patients to some extent.
- Subjects
RADIOTHERAPY; COGNITIVE ability; BRAIN metastasis; BRAIN cancer; HIPPOCAMPUS (Brain)
- Publication
Alternative Therapies in Health & Medicine, 2024, Vol 30, Issue 1, p111
- ISSN
1078-6791
- Publication type
Article