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- Title
Potential role for interferon gamma in the treatment of recurrent ventilator-acquired pneumonia in patients with COVID-19: a hypothesis.
- Authors
Nguyen, Lee S.; Ait Hamou, Zakaria; Gastli, Nabil; Chapuis, Nicolas; Pène, Frédéric
- Abstract
IFN-gamma treatment led to a fast increase in HLA-DR SP high sp monocytes in all but one patient with rapidly fatal septic shock (patient #3). Patients were assessed for mHLA-DR expression and were then administered interferon (IFN)-gamma to restore activated monocytes and thereby improve lung defense. IFN-gamma treatment was based on mHLA-DR expression, a reliable biomarker of post-aggressive immune suppression, thereby accounting for a good example of personalized medicine in critically ill patients.
- Subjects
COVID-19; VENTILATOR-associated pneumonia; INTERFERON gamma; RESPIRATORY infections
- Publication
Intensive Care Medicine, 2021, Vol 47, Issue 5, p619
- ISSN
0342-4642
- Publication type
letter
- DOI
10.1007/s00134-021-06377-3