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- Title
Co-treatment with Vitamin D Supplementation and Aerobic Training in Elderly Women with Vit D Deficiency and NAFLD: A Single-blind Controlled Trial.
- Authors
Hoseini, Zahra; Behpour, Nasser; Hoseini, Rastegar
- Abstract
Background: Lifestyle intervention is considered first-line therapy for Nonalcoholic Fatty Liver Disease (NAFL). Objectives: Here, we aimed to compare the effect of combined Aerobic Training (AT) and Vitamin D (Vit D) supplementation on NAFLD in elderly women with Vit D deficiency. Methods: We recruited 40 women (60 - 65 years) with NAFLD (second or third grade) and Vit D deficiency. Then, using simple randomization, the subjects were assigned to four groups including aerobic training (AT; 60% - 75%, 20 - 40 min/day, 3 days/wk running and walking), vitamin D supplementation (Vit D; 50,000 IU one day/week), aerobic training plus vitamin D supplementation (AT + Vit D), and sedentary control (C; placebo). The data were analyzed using paired t-test and one-way analysis of variance and Tukey's post hoc test with SPSS21 at a significance level of P < 0.05. Results: After eight weeks of intervention, fatty liver grade markedly reduced in the AT + VitD, AT, and VitDgroups (60%, 38.88%, and 22% respectively). However, it increased by 17.60% in the control group. The combination of AT + Vit D significantly reduced liver enzymes, anthropometric indices, and glycemic indices and improved lipid profile. All groups demonstrated a significant inverse correlation between vitamin D and fatty liver grade. Conclusions: A sedentary lifestyle and Vit D deficiency accelerate the NAFLD probably by deteriorating hepatic risk factors. Additionally, adequate levels of plasma vitamin D are necessary to achieve the beneficial metabolic effects of aerobic training.
- Subjects
FATTY liver prevention; AEROBIC exercises; ANTHROPOMETRY; COMBINED modality therapy; DIETARY supplements; GLYCEMIC index; LIPIDS; RUNNING; STATISTICAL sampling; STATISTICS; T-test (Statistics); VITAMIN D; VITAMIN D deficiency; WALKING; WOMEN'S health; DATA analysis; RANDOMIZED controlled trials; TREATMENT effectiveness; HUMAN research subjects; PATIENT selection; SEDENTARY lifestyles; DATA analysis software; ONE-way analysis of variance
- Publication
Hepatitis Monthly, 2020, Vol 20, Issue 2, p1
- ISSN
1735-143X
- Publication type
Article
- DOI
10.5812/hepatmon.96437