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- Title
DENSITATEA MINERALĂ OSOASĂ ŞI COMPOZIŢIA CORPULUI LA BOLNAVI CU SPONDILITŢ ANCHILOZANTĂ PRECOCE.
- Authors
Muntean, Laura; Simon, Siao-pin; Boloşiu, C. R.; Marinescu, C.; Gusho, Bianca; Nicoară, Ileana; Boloşiu, H. D.
- Abstract
Osteoporosis (OP) is a well-recognized feature of ankylosing spondylitis (AS), but the time of onset, predilect sites and pathogenesis remains controversial. Also the influence of disease on total body and soft tissue composition was only recently studied and there is little data in the current literature. Objectives: To determine total body and regional bone mineral density (BMD) and to examine the changes in body composition in a cohort of patients with early AS. Material and methods: Twenty-one patients (17 males, 4 pre-menopausal females) with AS without syndesmophytes and coxofemural joint destruction, with mean age 34 years, were compared with 21 sex- and age-matched controls. Lumbar spine and total hip BMD were evaluated by dual energy X-ray absorbtiometry with a Lunar Prodigy Advance device (GE). Total body measurements were done with the same device, and BMD of the whole body and body composition were studied. Results: In patients with early AS, BMD was reduced in both lumbar spine 1.11 ± 0.17 g/cm2 (T score -0.95 ± 1.52) and total hip 0.97 ± 0.12 g/cm2 (T score -0.63 ± 0.93) as compared with controls (1.24 ± 0.14 g/cm2 [T score 0.26 ± 1.2], respectively 1.07 ± 0.0 8 g/cm2 [T score 0.10 ± 0.85]; all p < 0.05). Total body BMD was also significantly lower in AS patients (p < 0.05). We found that total body BMD was correlated with spine BMD (r = 0.70, p = 0.006), but not with total hip BMD. On the contrary, bone mineral content (BMC), fat and lean masses did not differ between patients and controls (all p > 0.05). According to the WHO definition of osteoporosis, we found spine osteopenia or osteoporosis in 52.3% patients, while 38% had total hip osteopenia (none had total hip osteoporosis). No significant correlation was found between BMD at any site, variables of body composition and disease duration or biological markers of disease activity (erythrocyte sedimentation rate and C-reactive protein serum levels). Conclusions: AS is associated with generalzed bone loss that occurs early in the disease course. On the other hand, AS has no influence on the variables of body composition (BMC, fat and lean masses), at least not in the early stages of the disease.
- Subjects
OSTEOPOROSIS; ANKYLOSING spondylitis; BONES; MINERALS in the body; BODY composition; JOINT injuries; OSTEOPENIA; BIOMARKERS; RHEUMATOLOGY
- Publication
Romanian Journal of Rheumatology / Revista Romana de Reumatologie, 2007, Vol 16, Issue 3, p144
- ISSN
1843-0791
- Publication type
Article