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- Title
Articular manifestations in inflammatory bowel disease in children.
- Authors
Ignat, Ancuţa; Păduraru, Gabriela; Gimiga, Nicoleta; Ciubotariu, Gabriela; Lupu, Valeriu V.; Burlea, Marin
- Abstract
Inflammatory bowel disease (Crohn disease and ulcero-hemorrhagic rectocolitis) remains a chapter open to research due to its frequency (higher in the last decades), the clinical and evolutive particularities of digestive and extra digestive disorders, pathogenic enigma which represents a source of therapeutic difficulties. Specific genetic patterns and gene mutations favour the aberrant immune response to the antigens in the environment or the autoantigens causing bowel inflammations with high chronicization potential; the cytokines released and other still unknown mechanisms can be responsible for extra digestive disorders. The authors systematize recent data related to the pathogenesis of clinical evolutive types, modern diagnosis possibilities, the limits and the possibilities of modern therapeutic measures in arthropathies accompanying the inflammatory bowel disease.
- Subjects
INFLAMMATORY bowel diseases; JUVENILE diseases; GENETIC mutation; ARTHRITIS; IMMUNE response; CYTOKINES; AUTOANTIGENS
- Publication
Romanian Journal of Pediatrics / Revista Romana de Pediatrie, 2013, Vol 62, Issue 3, p253
- ISSN
1454-0398
- Publication type
Article