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- Title
Simultaneous Screening of 172 Veterinary Drugs by Modified QuEChERS-LC–MS/MS in TCM Galli Gigerii Endothelium Corneum.
- Authors
Hu, Qing; Sun, Jian; Yu, Hong; Feng, Rui; Zhang, Jingxian; Zhou, Heng; Ji, Shen
- Abstract
An analytical method was developed for the screening of 172 veterinary drugs in traditional Chinese medicine Galli Gigerii Endothelium Corneum by high-performance liquid chromatography tandem mass spectrometry. The samples were pretreated by a modified QuEChERS method. A Zorbax Eclipse plus C18 column (1.8 μm, 3.0 × 150 mm2, Agilent) was used for the separation of analytes by gradient elution. All analytes were detected by electrospray ionization mass spectrometry with multiple reaction monitoring mode. Good linearity with R ≥ 0.99 was exhibited for all analytes within the respective range. The recoveries of all monitored analytes ranged from 55.4 to 127.6% at three spiked levels (limit of quantitation—LOQ, 2-fold LOQ, 10-fold LOQ), with relative standard deviations <17.8%. The estimated LOQ levels were 0.2–20 μg/kg. The application of this method provides a reference for the safety control of traditional Chinese medicines.
- Subjects
VETERINARY drugs; ELECTROSPRAY ionization mass spectrometry; LIQUID chromatography-mass spectrometry; MEDICAL screening; HIGH performance liquid chromatography; CHINESE medicine; ENDOTHELIUM
- Publication
Journal of Chromatographic Science, 2024, Vol 62, Issue 5, p439
- ISSN
0021-9665
- Publication type
Article
- DOI
10.1093/chromsci/bmae014