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- Title
Prognostic value of epithelial‐mesenchymal transition‐inducing transcription factors in head and neck squamous cell carcinoma: A meta‐analysis.
- Authors
Wan, Yuehan; Liu, Haichao; Zhang, Ming; Huang, Zhengxian; Zhou, Han; Zhu, Yue; Tao, Yifan; Xie, Nan; Liu, Xiqiang; Hou, Jinsong; Wang, Cheng
- Abstract
Epithelial‐mesenchymal transition (EMT) plays a critical role in cancer progression and is primarily regulated by several EMT‐inducing transcription factors (EMT‐TFs), including TWIST1, TWIST2, SNAI1, SNAI2, ZEB1, and ZEB2. However, the prognostic value of EMT‐TFs remains controversial in head and neck squamous cell carcinoma (HNSCC). Studies on the prognostic role of EMT‐TFs in HNSCC were searched for in the Web of Science, Science Direct, Proquest, EMBASE, PubMed, and Cochrane Library. Meta‐analysis was performed by using Revman 5.2 software. The pooled analysis showed that overexpression of EMT‐TFs indicated a poor overall survival (OS) (HR = 1.93, 95% CI = 1.67‐2.23) of HNSCC. Subgroup analysis for individual EMT‐TFs revealed that overexpression of TWIST1 (HR = 1.61, 95% CI = 1.29‐2.02), SNAI1 (HR = 2.17, 95% CI = 1.63‐2.88), SNAI2 (HR = 1.90, 95% CI = 1.38‐2.62), and ZEB1 (HR = 2.70, 95% CI = 1.61‐4.53) were significantly associated with poor OS of HNSCC. These findings support the hypothesis that overexpression of EMT‐TFs indicates a poor prognosis for HNSCC patients.
- Subjects
SQUAMOUS cell carcinoma; TRANSCRIPTION factors; CANCER invasiveness; WEB search engines; META-analysis
- Publication
Head & Neck, 2020, Vol 42, Issue 5, p1067
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.26104