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- Title
Perineural antinociceptive effect of opioids in a rat model.
- Authors
Grant, G. J.; Vermeulen, K.; Zakowski, M. I.; Langerman, L.
- Abstract
<bold>Background: </bold>The research on conductive analgesia induced by perineural opioids generated a large body of conflicting data. In this study we reassessed the antinociceptive response to perineural administration of morphine, fentanyl or meperidine in a rat model.<bold>Methods: </bold>Analgesia was assessed using the hind paw withdrawal latency (HPWL) response to radiant heat. The opioid dose producing 20% of maximal possible effect (20%MPE) for systemic analgesia was calculated for each drug. Then sciatic blockade was performed with the dose corresponding to 20%MPE. The injected hind paw was used to measure direct perineural effect and the contralateral hind paw was used as an indicator of systemic effect.<bold>Results: </bold>The response latency produced by morphine or fentanyl was not significantly different for ipsilateral (perineural effect) or contralateral (systemic effect) paw (27+/-11 vs. 28+/-16 and 3l+/-16 vs. 23+/-16 s, respectively). However, the meperidine group showed significantly higher %MPE for the ipsilateral paw (79+/-32 s) than for the contralateral paw (27+/-22 s).<bold>Conclusions: </bold>The results indicate that perineural fentanyl or morphine do not produce analgesia. Perineural block produced by meperidine was attributed to local anesthetic-like effect, rather than to drug interaction with opioid receptor.
- Subjects
OPIOIDS; ANALGESIA; FENTANYL; MORPHINE; PHYSIOLOGY
- Publication
Acta Anaesthesiologica Scandinavica, 2001, Vol 45, Issue 7, p906
- ISSN
0001-5172
- Publication type
journal article
- DOI
10.1034/j.1399-6576.2001.045007906.x