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- Title
Understanding the Safety and Efficacy of Cyclosporine Versus Mycophenolate Mofetil in Patients with Renal Failure and Type II Diabetes Mellitus: A Systematic Review of Literature.
- Authors
Mahmood, Rana Kamran; Gillani, Syed Wasif; Saeed, Muhammad Waqas; Ahmad, Umar; Gulam, Shabaz Mohiuddin; Sam, Kishore Gnana
- Abstract
Purpose: The purpose of this systematic review is to compare the safety and efficacy of the cyclosporine and mycophenolate mofetil in patients with diabetes and renal failure. There is no work we found that compare the safety and efficacy of cyclosporine and mycophenolate in diabetic and renal failure patients. Method: Search was limited from 1983 to 2017 and articles must be in English. Articles searched from various resources and are evaluated using PRISMA. 25 articles selected and screened at the end 12 articles included in the study. Result: The result shows that the pharmacokinetics of cyclosporine is affected by the renal failure and diabetes and mycophenolate did not show much variation in pharmacokinetics. The safety of mycophenolate in renal patient in term of serum Creatinine is more than the cyclosporine and shifting of patient from cyclosporine to mycophenolate shows better result. Conclusion: It is concluded that mycophenolate is safer and more efficacious than cyclosporine in diabetic patients with renal failure.
- Subjects
AUTOIMMUNE diseases; CYCLOSPORINE; DRUG monitoring; MEDLINE; TYPE 2 diabetes; ONLINE information services; PATIENT safety; KIDNEY failure; SELF-efficacy; TRANSPLANTATION of organs, tissues, etc.; SYSTEMATIC reviews; MYCOPHENOLIC acid; PHARMACODYNAMICS
- Publication
International Medical Journal, 2020, Vol 27, Issue 6, p677
- ISSN
1341-2051
- Publication type
Article