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- Title
Carnitine Supplementation Treated with Valproic Acid Attenuate Antipsychotic-Induced Hyperprolactinemia in Psychiatric Setting.
- Authors
Masaru Nakamura; Takahiko Nagamine
- Abstract
Objective: The aim of this study was to investigate the effect of levocarnitine (active isoform of carnitine, L-Carnitine) supplementation on antipsychotic-induced hyperprolactinemia. Design: Levocarnitine was coadministrated over a period of three months in seventeen psychiatric inpatients treated with antipsychotics and valproic acid. Methods: Serum prolactin, ammonia, valproic acid, and free carnitine and acyicarnitine concentrations were measured at baseline and one and three months. Sequential change of their levels in addition to total carnitine and ratios of acylcarnitine/free carnitine were compared, and correlation between the levels of prolactin and ammonia or acylcarnitine/free carnitine against each baseline were analyzed. Results: Prolactin and ammonia levels were decreased, and free carnitine, acyicarnitine and total carnitine levels were significantly increased. The ratio of prolactin levels at one month against baseline was significantly negatively correlated with the ratio of acylcarnitine/free carnitine levels at one month against baseline, while no such correlations were found between prolactin levels and ammonia levels. Conclusion: In subjects with valproic acid-related hyperammonemia, carnitine supplementation attenuated antipsychotic-induced hyperprolactinemia, which may be associated with individual mitochondria function.
- Subjects
AMMONIA; ANTIPSYCHOTIC agents; CARNITINE; DIETARY supplements; PROLACTIN; PSYCHOTHERAPY patients; VALPROIC acid; PSYCHIATRIC treatment; TREATMENT duration; DATA analysis software
- Publication
International Medical Journal, 2017, Vol 24, Issue 2, p183
- ISSN
1341-2051
- Publication type
Article