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- Title
The Effects of Acute Malathion Exposure on Rat Cerebellum.
- Authors
Kasim, Fazlina; Hassan, Asma'
- Abstract
Objective: This study was conducted to determine the histopathological consequences of acute malathion exposure on the cerebellum of rats and its effects on the estimated total number of Purkinje cells in the cerebellum. Methodology: Ten adult female Wistar rats were treated with 250 mg/kg intraperitoneal malathion (corresponding to 0.2 of malathion's LD50) daily for seven consecutive days. In the control group, ten rats' received comparable volumes of 0.9% sodium chloride instead. Twenty-four hours after the seventh dose of malathion, the rats' cerebellum were taken for histopathological analysis and estimation of the total number of Purkinje cells in each cerebellum. Results: Rats exposed to malathion showed significant deficits in body weight compared to rats in the control group (t = 4.267, p < 0.001). Histopathological changes were not seen in cerebellum of rats exposed to malathion. There was also no statistically significant difference in the estimated total number of Purkinje cells between the malathion-exposed and control groups. Conclusion: It was concluded that the dose of malathion and the duration of exposure used in this experiment did not have any significant effect on the histopathology of the cerebellum and the total numbers of Purkinje cells in the cerebellum of rats.
- Subjects
CEREBELLUM anatomy; ANIMAL experimentation; CEREBELLUM; MALATHION; RATS
- Publication
International Medical Journal, 2016, Vol 23, Issue 5, p556
- ISSN
1341-2051
- Publication type
Article