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- Title
Blunted Muscle Mitochondrial Responses to Exercise Training in Older Adults With HIV.
- Authors
Jankowski, Catherine M; Wilson, Melissa P; MaWhinney, Samantha; Reusch, Jane; Knaub, Leslie; Hull, Sara; Erlandson, Kristine M
- Abstract
<bold>Background: </bold>Muscle mitochondrial dysfunction associated with HIV and antiretroviral therapy (ART) may improve with exercise.<bold>Methods: </bold>Muscle specimens obtained before and after 24 weeks of exercise in older people with HIV (PWH; n = 18; ART >2 years) and uninfected controls (n = 21) were analyzed for citrate synthase (CS) activity and complexes (C) I-V, manganese superoxide dismutase (MnSOD), peroxisome proliferator-activated receptor-γ coactivator-1 (PGC1α), and voltage-dependent anion channel 1 (VDAC1) content.<bold>Results: </bold>Only controls had increased CS, MnSOD, PGC1α, and CIV (P ≤ .01; P < .01 vs PWH) after training.<bold>Conclusions: </bold>The blunted mitochondrial adaptations to training in PWH suggests the need for different types of exercise-induced stimulation.<bold>Clinical Trials Registration: </bold>NCT02404792.
- Subjects
OLDER people; CLINICAL trial registries; MITOCHONDRIA; CITRATE synthase; HIV
- Publication
Journal of Infectious Diseases, 2021, Vol 224, Issue 4, p679
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiaa799