We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Rapid Progression of Kidney Dysfunction in People Living With HIV: Use of Polygenic and Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) Risk Scores.
- Authors
Dietrich, Léna G; Thorball, Christian W; Ryom, Lene; Burkhalter, Felix; Hasse, Barbara; Thurnheer, Maria Christine; Weisser, Maja; Schmid, Patrick; Bernasconi, Enos; Darling, Kathrine E A; Buvelot, Hélène; Fellay, Jacques; Ledergerber, Bruno; Tarr, Philip E; Study, Swiss HIV Cohort; Swiss HIV Cohort Study
- Abstract
<bold>Background: </bold>In people with human immunodeficiency virus (PWH), it is unknown whether genetic background associates with rapid progression of kidney dysfunction (ie, estimated glomerular filtration rate [eGFR] decrease of >5mL/min/1.73m2 per year for ≥3 consecutive years).<bold>Methods: </bold>We obtained univariable and multivariable hazard ratios (HR) for rapid progression, based on the clinical D:A:D chronic kidney disease (CKD) risk score, antiretroviral exposures, and a polygenic risk score based on 14 769 genome-wide single nucleotide polymorphisms in white Swiss HIV Cohort Study participants.<bold>Results: </bold>We included 225 participants with rapid progression and 3378 rapid progression-free participants. In multivariable analysis, compared to participants with low D:A:D risk, participants with high risk had rapid progression (HR = 1.82 [95% CI, 1.28-2.60]). Compared to the first (favorable) polygenic risk score quartile, participants in the second, third, and fourth (unfavorable) quartiles had rapid progression (HR = 1.39 [95% CI, 0.94-2.06], 1.52 [95% CI, 1.04-2.24], and 2.04 [95% CI, 1.41-2.94], respectively). Recent exposure to tenofovir disoproxil fumarate was associated with rapid progression (HR = 1.36 [95% CI, 1.06-1.76]).<bold>Discussion: </bold>An individual polygenic risk score is associated with rapid progression in Swiss PWH, when analyzed in the context of clinical and antiretroviral risk factors.
- Subjects
SWITZERLAND; HIV-positive persons; DRUG side effects; HIV; SINGLE nucleotide polymorphisms; ACQUISITION of data; HIV infection complications; HIV infections; ANTI-HIV agents; GLOMERULAR filtration rate; DISEASE progression; RESEARCH; KIDNEYS; RESEARCH methodology; GENETIC polymorphisms; EVALUATION research; KIDNEY diseases; COMPARATIVE studies; RESEARCH funding; LONGITUDINAL method; DISEASE complications
- Publication
Journal of Infectious Diseases, 2021, Vol 223, Issue 12, p2145
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiaa695