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- Title
Synthesis and Antitumor Activity of Dehydroepiandrosterone Derivatives on Es-2, A549, and HepG2 Cells in vitro.
- Authors
Liu, Xue-Kun; Ye, Bai-Jun; Wu, Yan; Nan, Ji-Xing; Lin, Zhen-Hua; Piao, Hu-Ri
- Abstract
A series of dehydroepiandrosterone derivatives containing an acid ester was synthesized and evaluated for their antitumor activity on ES-2, A549, and HepG2 cells by the MTT assay. Most compounds showed antitumor activity, while compounds 1c, 2i, and 2o exhibited more potential inhibitory effects compared with dehydroepiandrosterone on ES-2 cells, A549 cells, and HepG2 cells, respectively.
- Subjects
ANTINEOPLASTIC agents; ADRENOCORTICAL hormones; DEHYDROEPIANDROSTERONE; CHEMICAL synthesis; CHEMICAL biology
- Publication
Chemical Biology & Drug Design, 2012, Vol 79, Issue 4, p523
- ISSN
1747-0277
- Publication type
Article
- DOI
10.1111/j.1747-0285.2011.01311.x