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- Title
A molecular sensitization map of European children reveals exposome‐ and climate‐dependent sensitization profiles.
- Authors
Kiewiet, M. B. Gea; Lupinek, Christian; Vrtala, Susanne; Wieser, Sandra; Baar, Alexandra; Kiss, Renata; Kull, Inger; Melén, Erik; Wickman, Magnus; Porta, Daniela; Gori, Davide; Gehring, Ulrike; Aalberse, Rob; Sunyer, Jordi; Standl, Marie; Heinrich, Joachim; Waiblinger, Dagmar; Wright, John; Antó, Josep M.; Bousquet, Jean
- Abstract
Background: Understanding differences in sensitization profiles at the molecular allergen level is important for diagnosis, personalized treatment and prevention strategies in allergy. Methods: Immunoglobulin E (IgE) sensitization profiles were determined in more than 2800 sera from children in nine population‐based cohorts in different geographical regions of Europe; north [BAMSE (Sweden), ECA (Norway)], west/central [PIAMA (the Netherlands), BiB (the United Kingdom), GINIplus (Germany)], and south [INMA Sabadell and Gipuzkoa (Spain) and ROBBIC Rome and Bologna (Italy)] using the MeDALL‐allergen chip. Results: Sensitization to grass pollen allergen, Phl p 1, and to major cat allergen, Fel d 1, dominated in most European regions whereas sensitization to house dust mite allergens Der p 1, 2 and 23 varied considerably between regions and were lowest in the north. Less than half of children from Sabadell which has a hot and dry climate were sensitized to respiratory allergens, in particular house dust mite allergens as compared to Gipuzkoa nearby with a more humid climate. Peanut allergen Ara h 1 was the most frequently recognized class 1 food allergen in Northern/Western Europe, while the fruit allergens Pru p 3, Act d 1 and 2 were prominent in Southern and Western/Central Europe. Ves v 5‐sensitization dominated in North and West/Central Europe. Conclusion: We show regional, exposome‐ and climate‐dependent differences in molecular IgE‐reactivity profiles in Northern, Western/Central and Southern Europe which may form a molecular basis for precision medicine‐based approaches for treatment and prevention of allergy.
- Subjects
EUROPE; GENE mapping; HOUSE dust mites; IMMUNOGLOBULIN E; WESTERN diet; ALLERGENS; MEDICAL climatology
- Publication
Allergy, 2023, Vol 78, Issue 7, p2007
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/all.15689