We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The impact of maternal‐fetal omalizumab transfer on peanut‐specific responses in an ex vivo placental perfusion model.
- Authors
Kothari, Akash; Hirschmugl, Birgit; Lee, Jean‐Soo; Pfaller, Birgit; Schmidthaler, Klara; Szépfalusi, Zsolt; Wadsack, Christian; Eiwegger, Thomas
- Abstract
Activation levels are expressed as %CD63+ basophils in PE, PE/PA, and PE/PA/Oma experiments. gl The transferred peanut proteins were fully capable of crosslinking IgE as confirmed via BAT (Figure 2B). Abbreviations BAT basophil activation test FcRn neonatal Fc receptors Oma omalizumab The transport of maternal IgG to the fetus is mediated by neonatal Fc receptors (FcRn) expressed on the placenta, which provides passive immunity in utero. Evidence that FcRn mediates the transplacental passage of maternal IgE in the form of IgG anti-IgE/IgE immune complexes.
- Subjects
OMALIZUMAB; PLACENTA; PERFUSION; PREGNANCY proteins; IMMUNE complexes
- Publication
Allergy, 2022, Vol 77, Issue 12, p3684
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/all.15468