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- Title
Brain activation after nasal histamine provocation in house dust mite allergic rhinitis patients.
- Authors
Callebaut, Ina; Steelant, Brecht; Backaert, Wout; Peeters, Ronald; Sunaert, Stefan; Van Oudenhove, Lukas; Hellings, Peter W
- Abstract
Most of these differential responses were due to stronger activation in HCs vs AR patients, except for the right anterior insula, right middle occipital gyrus, right middle/superior frontal gyrus, and left cerebellum, where a stronger activation was observed in AR patients. Further research in a larger group of patients might be useful to investigate brain responses in severe AR patients and to better understand the psycho-emotional impact of chronic allergic inflammation. In allergic rhinitis (AR) patients, nasal allergen deposition leads to mast cell activation with release of allergic mediators such as histamine. In this proof-of-concept study, 8 house dust mite (HDM) AR patients and 7 non-allergic healthy controls (HC) were recruited at the outpatient clinic for Otorhinolaryngology of University Hospitals Leuven.
- Subjects
SNEEZING; ITCHING; HOUSE dust mites; ALLERGIC rhinitis; HISTAMINE; PROVOCATION tests (Medicine); MOTOR cortex
- Publication
Allergy, 2021, Vol 76, Issue 6, p1879
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/all.14677