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- Title
The effect of lidocaine on remifentanil-induced cough.
- Authors
Kim, J. Y.; Park, K. S.; Kim, J. S.; Park, S. Y.; Kim, J. W.
- Abstract
This study was performed to investigate the incidence of remifentanil-induced cough and evaluate the efficacy of lidocaine on its prevention. Five-hundred patients, aged 18–70 years, were randomly allocated into two groups to receive either lidocaine 0.5 mg.kg−1 or 0.9% normal saline intravenously 1 min before remifentanil administration at a target effect-site concentration of 4 ng.ml−1. Any episode of cough was classified as coughing and graded as mild (1–2), moderate (3–4) or severe (5 or more). We found that the overall incidence of cough was significantly higher in the saline group (69 patients; 27.6%) than that in the lidocaine group (38 patients; 15.2%) (p < 0.001). The results of logistic regression indicated that age and smoking were associated with remifentanil-induced cough. This study demonstrated that intravenously administered lidocaine 0.5 mg.kg−1 effectively suppresses remifentanil-induced cough without possible systemic lidocaine toxicity.
- Subjects
LIDOCAINE; COUGH; ACETANILIDE; PATIENTS; MEDICAL care
- Publication
Anaesthesia, 2008, Vol 63, Issue 5, p495
- ISSN
0003-2409
- Publication type
Article
- DOI
10.1111/j.1365-2044.2007.05414.x