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- Title
Retreatment With Varenicline for Smoking Cessation in Smokers Who Have Previously Taken Varenicline: A Randomized, Placebo-Controlled Trial.
- Authors
Gonzales, D; Hajek, P; Pliamm, L; Nackaerts, K; Tseng, L‐J; McRae, T D; Treadow, J
- Abstract
The efficacy and safety of retreatment with varenicline in smokers attempting to quit were evaluated in this randomized, double-blind, placebo-controlled, multicenter trial (Australia, Belgium, Canada, the Czech Republic, France, Germany, the United Kingdom, and the United States). Participants were generally healthy adult smokers (≥10 cigarettes/day) with ≥1 prior quit attempt (≥2 weeks) using varenicline and no quit attempts in ≤3 months; they were randomly assigned (1:1) to 12 weeks' varenicline (n = 251) or placebo (n = 247) treatment, with individual counseling, plus 40 weeks' nontreatment follow-up. The primary efficacy end point was the carbon monoxide-confirmed (≤10 ppm) continuous abstinence rate for weeks 9-12, which was 45.0% (varenicline; n = 249) vs. 11.8% (placebo; n = 245; odds ratio: 7.08; 95% confidence interval: 4.34, 11.55; P < 0.0001). Common varenicline group adverse events were nausea, abnormal dreams, and headache, with no reported suicidal behavior. Varenicline is efficacious and well tolerated in smokers who have previously taken it. Abstinence rates are comparable with rates reported for varenicline-naive smokers.
- Subjects
VARENICLINE; SMOKING cessation; BENZAZEPINES; TOBACCO chewing; CIGARETTE smokers; ELECTRONIC cigarettes
- Publication
Clinical Pharmacology & Therapeutics, 2014, Vol 96, Issue 3, p390
- ISSN
0009-9236
- Publication type
Article
- DOI
10.1038/clpt.2014.124