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- Title
Decreased Skeletal Muscle Mitochondrial DNA in Patients Treated with High-Dose Simvastatin.
- Authors
Schick, B. A.; Laaksonen, R.; Frohlich, J. J.; Päivä, H.; Lehtimäki, T.; Humphries, K. H.; Côté, H. C. F.
- Abstract
Statins are generally well tolerated, but can cause myopathy1 and have been associated with mitochondrial abnormalities.2, 3, 4, 5, 6 The aim of this study was to determine whether muscle mitochondrial DNA (mtDNA) levels are altered during statin therapy. We retrospectively quantified mtDNA in 86 skeletal muscle biopsy specimens collected as part of a previously published7 clinical trial of high-dose simvastatin or atorvastatin versus placebo.Clinical Pharmacology & Therapeutics (2007) 81, 650–653. doi:10.1038/sj.clpt.6100124; published online 28 February 2007
- Subjects
STATINS (Cardiovascular agents); MUSCLE diseases; MITOCHONDRIAL DNA abnormalities; GENETIC disorders; CLINICAL pharmacology
- Publication
Clinical Pharmacology & Therapeutics, 2007, Vol 81, Issue 5, p650
- ISSN
0009-9236
- Publication type
Article
- DOI
10.1038/sj.clpt.6100124