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- Title
Evaluation of Insulin Sensitivity and β-Cell Function Indexes Obtained From Minimal Model Analysis of a Meal Tolerance Test.
- Authors
Steil, Garry M.; Hwu, Chi-min; Janowski, Robert; Hariri, Farzam; Jinagouda, Sujata; Darwin, Christine; Tadros, Sameh; Rebrin, Kerstin; Saad, Mohammed F.
- Abstract
Modeling analysis of glucose, insulin, and C-peptide following a meal has been proposed as a means to estimate insulin sensitivity (Si) and β-cell function from a single test. We compared the model-derived meal indexes with analogous indexes obtained from an intravenous glucose tolerance test (IVGTT) and hyperglycemic clamp (HGC) in 17 nondiabetic subjects (14 men, 3 women, aged 50 ± 2 years [mean ± SE], BMI 25.0 ± 0.7 kg/m2). Si estimated from the meal was correlated with Si estimated from the IVGTT and the HGC (r = 0.59 and 0.76, respectively; P < 0.01 for both) but was ∼2.3 and 1.4 thales higher (P < 0.05 for both). The meal-derived estimate of the β-cell's response to a steady-state change in glucose (static secretion index) was correlated with the HGC second-phase insulin response (r = 0.69; P = 0.002), but the estimated rate-of-change component (dynamic secretion index) was not correlated with first-phase insulin release from either the HGC or IVGTT. Indexes of β-cell function obtained from the meal were significantly higher than those obtained from the HGC. In conclusion, insulin sensitivity and β-cell indexes derived from a meal are not analogous to those from the clamp or IVGTT. Further work is needed before these indexes can be routinely used in clinical and epidemiological studies.
- Subjects
INSULIN; PANCREATIC beta cells; C-peptide; TYPE 2 diabetes; DIAGNOSIS of diabetes; GLUCOSE tolerance tests; GLUCOSE; BLOOD sugar
- Publication
Diabetes, 2004, Vol 53, Issue 5, p1201
- ISSN
0012-1797
- Publication type
Article
- DOI
10.2337/diabetes.53.5.1201