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- Title
Heritability of multivariate factors of the metabolic syndrome in nondiabetic Japanese americans.
- Authors
Austin, Melissa A.; Edwards, Karen L.; McNeely, Marguerite J.; Chandler, Wayne L.; Leonetti, Donna L.; Talmud, Philippa J.; Humphries, Steve E.; Fujimoto, Wilfred Y.
- Abstract
A rapidly growing body of evidence demonstrates important associations between the metabolic syndrome, characterized by a cluster of risk factors or phenotypes that include dyslipidemia, central obesity, hypertension, and hyperinsulinemia, and both cardiovascular disease and type 2 diabetes. The purpose of the present study was to characterize the metabolic syndrome in a sample of 432 individuals from 68 Japanese-American families, using factor analysis of quantitative phenotypes, and to estimate the heritability of these independent factors. Using nine characteristic phenotypes that included LDL particle size and C-reactive protein (CRP), factor analysis identified three multivariate factors interpreted as lipids, body fat/insulin/glucose/CRP, and blood pressure, explaining 65% of the variance. Heritability analysis revealed significant genetic effects on all of the factors: lipids (h&sup2 = 0.52, P < 0.001), body fat/insulin/glucose/CRP (h² = 0.27, P = 0.016), and blood pressure (h² = 0.25, P = 0.026). This analysis shows that independent, multivariate factors of the metabolic syndrome are heritable, demonstrating genetic influences on the underlying pathophysiological mechanisms of the syndrome.
- Subjects
UNITED States; METABOLISM; BIOCHEMISTRY; ETHNOLOGY; PHENOTYPES; TYPE 2 diabetes
- Publication
Diabetes, 2004, Vol 53, Issue 4, p1166
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/diabetes.53.4.1166