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Building and validating a prediction model for paediatric type 1 diabetes risk using next generation targeted sequencing of class II HLA genes.
Published in:
2017
By:
- Zhao, Lue Ping;
- Carlsson, Annelie;
- Larsson, Helena Elding;
- Forsander, Gun;
- Ivarsson, Sten A.;
- Kockum, Ingrid;
- Ludvigsson, Johnny;
- Marcus, Claude;
- Persson, Martina;
- Samuelsson, Ulf;
- Örtqvist, Eva;
- Pyo, Chul‐Woo;
- Bolouri, Hamid;
- Zhao, Michael;
- Nelson, Wyatt C.;
- Geraghty, Daniel E.;
- Lernmark, Åke;
- Örtqvist, Eva;
- Pyo, Chul-Woo;
- Lernmark, Åke
Publication type:
journal article
Genetic and perinatal factors as risk for childhood type 1 diabetes.
Published in:
Diabetes/Metabolism Research & Reviews, 2004, v. 20, n. 6, p. 429, doi. 10.1002/dmrr.506
By:
- Larsson, Karin;
- Elding-Larsson, Helena;
- Cederwall, Elisabeth;
- Kockum, Karin;
- Neiderud, Jan;
- Sjöblad, Sture;
- Lindberg, Bengt;
- Lernmark, Barbro;
- Cilio, Corrado;
- Ivarsson, Sten-A.;
- Lernmark, Åke
Publication type:
Article
The development of a World Health Organisation international standard for islet cell antibodies: the aims and design of an international collaborative study.
Published in:
1999
By:
- Mire-Sluis, Anthony R.;
- Das, Rose Gaines;
- Lernmark, Åke;
- Mire-Sluis, A R;
- Das, R G;
- Lernmark, A
Publication type:
journal article
The type 1 diabetes protective HLA DQB1*0602 allele is less frequent in gestational diabetes mellitus.
Published in:
Diabetologia, 2009, v. 52, n. 7, p. 1339, doi. 10.1007/s00125-009-1351-6
By:
- Papadopoulou, A.;
- Lynch, K.;
- Shaat, N.;
- Nilsson, A.;
- Lernmark, B.;
- Berntorp, K.;
- Ivarsson, S.-A.;
- Agardh, C.-D.;
- Lernmark, Å.
Publication type:
Article
Diabetes-associated HLA genotypes affect birthweight in the general population.
Published in:
Diabetologia, 2005, v. 48, n. 8, p. 1484, doi. 10.1007/s00125-005-1813-4
By:
- Larsson, H. E.;
- Lynch, K.;
- Lernmark, B.;
- Nilsson, A.;
- Hansson, G.;
- Almgren, P.;
- Lernmark, Å.;
- Ivarsson, S.-A.
Publication type:
Article
Cord blood islet autoantibodies and seasonal association with the type 1 diabetes high-risk genotype.
Published in:
Journal of Perinatology, 2008, v. 28, n. 3, p. 211, doi. 10.1038/sj.jp.7211912
By:
- Lynch, K. F.;
- Lernmark, B.;
- Merlo, J.;
- Cilio, C. M.;
- Ivarsson, S.-A.;
- Lernmark, Å.
Publication type:
Article
Cord Blood Islet Autoantibodies Are Related to Stress in the Mother during Pregnancy.
Published in:
Annals of the New York Academy of Sciences, 2006, v. 1079, n. 1, p. 345, doi. 10.1196/annals.1375.053
By:
- LERNMARK, BARBRO;
- LYNCH, KRISTIAN;
- LERNMARK, Å KE
Publication type:
Article
Islet cell autoantibody levels after the diagnosis of young adult diabetic patients.
Published in:
Diabetic Medicine, 2007, v. 24, n. 11, p. 1221, doi. 10.1111/j.1464-5491.2007.02235.x
By:
- Jensen, R.;
- Gilliam, L.;
- Torn, C.;
- Landin-Olsson, M.;
- Palmer, J.;
- Åkesson, K.;
- Kockum, I.;
- Lernmark, B.;
- Karlsson, A. F.;
- Lynch, K. F.;
- Breslow, N.;
- Lernmark, Å.;
- Sundkvist, G.
Publication type:
Article
Susceptibility to insulin-dependent diabetes defined by restriction enzyme polymorphism of HLA-D region genomic DNA.
Published in:
1984
By:
- Owerbach, David;
- Hägglöf, Bruno;
- Lernmark, Åke;
- Holmgren, Gösta;
- Owerbach, D;
- Hägglöf, B;
- Lernmark, A;
- Holmgren, G
Publication type:
journal article
A prospective analysis of islet-cell cytotoxic antibodies in insulin-dependent diabetic children. Transient effects of plasmapheresis.
Published in:
1984
By:
- Rabinovitch, Alexander;
- MacKay, Peter;
- Ludvigsson, Johnny;
- Lernmark, Åke;
- Rabinovitch, A;
- MacKay, P;
- Ludvigsson, J;
- Lernmark, A
Publication type:
journal article
Immunoglobulin from insulin-dependent diabetic children inhibits glucose-induced insulin release.
Published in:
1983
By:
- Kanatsuna, Takahiro;
- Bækkeskov, Steinunn;
- Lernmark, Åke;
- Ludvigsson, Johnny;
- Kanatsuna, T;
- Baekkeskov, S;
- Lernmark, A;
- Ludvigsson, J
Publication type:
journal article
Islet cell surface antibodies and lymphocyte antibodies in the spontaneously diabetic BB Wistar rat.
Published in:
1982
By:
- Dyrberg, Thomas;
- Nakhooda, Azima F.;
- Baekkeskov, Steinunn;
- Lernmark, Åke;
- Poussier, Philippe;
- Marliss, Errol B.;
- Dyrberg, T;
- Nakhooda, A F;
- Baekkeskov, S;
- Lernmark, A;
- Poussier, P;
- Marliss, E B
Publication type:
journal article
A major loss in islet mass and B-cell function precedes hyperglycemia in mice given multiple low doses of streptozotocin.
Published in:
1981
By:
- Bonnevie-Nielsen, Vagn;
- Steffes, Michael W.;
- Lernmark, Åke;
- Bonnevie-Nielsen, V;
- Steffes, M W;
- Lernmark, A
Publication type:
journal article
Block in insulin release from column-perifused pancreatic beta-cells induced by islet cell surface antibodies and complement.
Published in:
1981
By:
- Kanatsuna, Takahiro;
- Lernmark, Åke;
- Rubenstein, Arthur H.;
- Steiner, Donald F.;
- Kanatsuna, T;
- Lernmark, A;
- Rubenstein, A H;
- Steiner, D F
Publication type:
journal article
High GAD65 autoantibody levels in nondiabetic adults are associated with HLA but not with CTLA-4 or INS VNTR.
Published in:
2003
By:
- Rolandsson, O.;
- Hägg, E.;
- Janer, M.;
- Rutledge, E.;
- Gaur, L. K.;
- Nilsson, M.;
- Hallmans, G.;
- Lernmark, Å.;
- Hägg, E;
- Lernmark, A
Publication type:
journal article
Prediction of diabetes with body mass index, oral glucose tolerance test and islet cell autoantibodies in a regional population.
Published in:
2001
By:
- Rolandsson, O.;
- Hägg, E.;
- Nilsson, M.;
- Hallmans, G.;
- Mincheva-Nilsson, L.;
- Lernmark, Å.;
- Hägg, E;
- Lernmark, A
Publication type:
journal article
Tissue transglutaminase immunoglobulin isotypes in children with untreated and treated celiac disease.
Published in:
2003
By:
- Agardh, Daniel;
- Borulf, Stefan;
- Lernmark, Åke;
- Ivarsson, Sten A.;
- Lernmark, Ake
Publication type:
journal article
GAD65 antibody epitope patterns of type 1.5 diabetic patients are consistent with slow-onset autoimmune diabetes.
Published in:
2002
By:
- Hampe, Christiane S.;
- Kockum, Ingrid;
- Landin-Olsson, Mona;
- Torn, Carina;
- Örtqvist, Eva;
- Persson, Bengt;
- Rolandsson, Olov;
- Palmer, Jerry;
- Lernmark, Åke;
- Törn, Carina;
- Ortqvist, Eva;
- Lernmark, Ake
Publication type:
Letter
Stability of disease-associated antibody titers in pregnant women with type 1 diabetes with or without residual beta-cell function.
Published in:
2000
By:
- NOVAK, ERIK J.;
- ÖRTQVIST, EVA;
- NORD, EVA;
- EDWALL, LENA;
- HAMPE, CHRISTIANE S.;
- BEKRIS, LYNN;
- PERSSON, BENGT E.;
- LERNMARK, ÅKE;
- Novak, E J;
- Ortqvist, E;
- Nord, E;
- Edwall, L;
- Hampe, C S;
- Bekris, L;
- Persson, B E;
- Lernmark, A
Publication type:
research
Antibodies to GAD and glycemic control in recent-onset IDDM.
Published in:
1997
By:
- Hoeldtke, Robert D.;
- Bryner, Kimberly D.;
- Horvath, Gabriella G.;
- Byerly, Michele R.;
- Hobbs, Gerald R.;
- Marcovina, Santica M.;
- Lernmark, Ake;
- Hoeldtke, R D;
- Bryner, K D;
- Horvath, G G;
- Byerly, M R;
- Hobbs, G R;
- Marcovina, S M;
- Lernmark, A
Publication type:
journal article
Associations of GAD65- and IA-2- autoantibodies with genetic risk markers in new-onset IDDM patients and their siblings. The Belgian Diabetes Registry.
Published in:
1997
By:
- Vandewalle, Christina L.;
- Falorni, Alberto;
- Lernmark, Åke;
- Goubert, Patrick;
- Dorchy, Harry;
- Coucke, Willy;
- Semakula, Crispin;
- Van Der Auwera, Bart;
- Kaufman, Leon;
- Schuit, Frans C.;
- Pipeleers, Daniel G.;
- Gorus, Frans K.;
- Vandewalle, C L;
- Falorni, A;
- Lernmark, A;
- Goubert, P;
- Dorchy, H;
- Coucke, W;
- Semakula, C;
- Van der Auwera, B
Publication type:
journal article
Glutamic acid decarboxylase antibodies and diabetes complications. Assay reliability and validity.
Published in:
1995
By:
- Lernmark, Åke;
- Lernmark, A
Publication type:
journal article
Autoantibodies in diabetes.
Published in:
2005
By:
- Pihoker, Catherine;
- Gilliam, Lisa K.;
- Hampe, Christiane S.;
- Lernmark, Åke;
- Lernmark, Ake
Publication type:
journal article
Gene and cell-replacement therapy in the treatment of type 1 diabetes: how high must the standards be set?
Published in:
2001
By:
- Halban, Philippe A.;
- Kahn, Steven E.;
- Lernmark, Ake;
- Rhodes, Christopher J.;
- Halban, P A;
- Kahn, S E;
- Lernmark A;
- Rhodes, C J
Publication type:
journal article
GAD65-specific autoantibodies enhance the presentation of an immunodominant T-cell epitope from GAD65.
Published in:
2000
By:
- Reijonen, Helena;
- Daniels, Terri L.;
- Lernmark, Ake;
- Nepom, Gerald T.;
- Reijonen, H;
- Daniels, T L;
- Lernmark, A;
- Nepom, G T
Publication type:
journal article
Auto- and alloimmune reactivity to human islet allografts transplanted into type 1 diabetic patients.
Published in:
1999
By:
- Roep, Bart O.;
- Stobbe, Inge;
- Duinkerken, Gaby;
- van Rood, Jon J.;
- Lernmark, Ake;
- Keymeulen, Bart;
- Pipeleers, Danny;
- Claas, Frans H.J.;
- de Vries, Rene R.P.;
- Roep, B O;
- Stobbe, I;
- Duinkerken, G;
- van Rood, J J;
- Lernmark, A;
- Keymeulen, B;
- Pipeleers, D;
- Claas, F H;
- de Vries, R R
Publication type:
journal article
Recombinant human platelet-activating factor acetylhydrolase reduces the frequency of diabetes in the diabetes-prone BB rat.
Published in:
1999
By:
- Lee, Edmond S.;
- Jiang, Jianjie;
- Sund, Greg C.;
- Simonson, William T.;
- Graham, Jinko;
- Dietsch, Greg;
- Schimpf, Brian;
- Bieg, Sabine;
- Peterman, Gary;
- Lernmark, Ake;
- Lee, E S;
- Jiang, J;
- Sund, G C;
- Simonson, W T;
- Graham, J;
- Dietsch, G;
- Schimpf, B;
- Bieg, S;
- Peterman, G;
- Lernmark, A
Publication type:
journal article
Polymorphic amino acid variations in HLA-DQ are associated with systematic physical property changes and occurrence of IDDM. Members of the Swedish Childhood Diabetes Study.
Published in:
1995
By:
- Sanjeevi, Carani B.;
- Lybrand, Terry P.;
- DeWeese, Carol;
- Landin-Olsson, Mona;
- Kockum, Ingrid;
- Dahlquist, Gisela;
- Sundkvist, Göran;
- Stenger, David;
- Lernmark, Åke;
- Sanjeevi, C B;
- Lybrand, T P;
- DeWeese, C;
- Landin-Olsson, M;
- Kockum, I;
- Dahlquist, G;
- Sundkvist, G;
- Stenger, D;
- Lernmark, A
Publication type:
journal article
Improved specificity of ICA assays in the Fourth International Immunology of Diabetes Serum Exchange Workshop.
Published in:
1992
By:
- Greenbaum, Carla J.;
- Palmer, Jerry P.;
- Nagataki, S.;
- Yamaguchi, Y.;
- Molenaar, J. L.;
- Van Beers, W. A. M.;
- MacLaren, Noel K.;
- Lernmark, Åke;
- Greenbaum, C J;
- Palmer, J P;
- Van Beers, W A;
- MacLaren, N K;
- Lernmark, A
Publication type:
journal article
Recombinant glutamic acid decarboxylase (representing the single isoform expressed in human islets) detects IDDM-associated 64,000-M(r) autoantibodies.
Published in:
1992
By:
- Karlsen, Allan E.;
- Hagopian, William A.;
- Petersen, Jacob S.;
- Boel, Esper;
- Dyrberg, Thomas;
- Grubin, Catherine E.;
- Michelsen, Birgitre K.;
- Madsen, Ole D.;
- Lernmark, Åke;
- Karlsen, A E;
- Hagopian, W A;
- Petersen, J S;
- Boel, E;
- Dyrberg, T;
- Grubin, C E;
- Michelsen, B K;
- Madsen, O D;
- Lernmark, A
Publication type:
journal article
Islet cell and thyrogastric antibodies in 633 consecutive 15- to 34-yr-old patients in the diabetes incidence study in Sweden.
Published in:
1992
By:
- Landin-Olsson, Mona;
- Karlsson, F. Anders;
- Lernmark, Åke;
- Sundkvist, Göran;
- Landin-Olsson, M;
- Karlsson, F A;
- Lernmark, A;
- Sundkvist, G
Publication type:
journal article
Lack of systematically found insulin autoantibodies in spontaneously diabetic BB rats.
Published in:
1990
By:
- Markholst, Helle;
- Klaff, Leslie J.;
- Klöppel, Günter;
- Lernmark, Åke;
- Mordes, John P.;
- Palmer, Jerry;
- Markholst, H;
- Klaff, L J;
- Klöppel, G;
- Lernmark, A;
- Mordes, J P;
- Palmer, J
Publication type:
journal article
Association of IDDM and attenuated response of 2',5'-oligoadenylate synthetase to yellow fever vaccine.
Published in:
1989
By:
- Bonnevie-Nielsen, V.;
- Larsen, M. L.;
- Frifelt, J. J.;
- Michelsen, B.;
- Lernmark, Å.;
- Lernmark, A
Publication type:
journal article
Nonislet pancreatic autoantibodies in sibship with permanent neonatal insulin-dependent diabetes mellitus.
Published in:
1988
By:
- Ivarsson, Sten-A.;
- Marner, Bente;
- Lernmark, Åke;
- Nilsson, Karl Olof;
- Ivarsson, S A;
- Marner, B;
- Lernmark, A;
- Nilsson, K O
Publication type:
journal article
Spontaneously diabetic BB rats have age-dependent islet beta-cell-specific surface antibodies at clinical onset.
Published in:
1987
By:
- Pipeleers, Daniel;
- Van De Winkel, Marnix;
- Dyrberg, Thomas;
- Lernmark, Ånke;
- Pipeleers, D;
- Van de Winkel, M;
- Dyrberg, T;
- Lernmark, A
Publication type:
journal article
Tissue transglutaminase autoantibodies and human leucocyte antigen in Down's syndrome patients with coeliac disease.
Published in:
2002
By:
- Agardh, D;
- Nilsson, A;
- Carlsson, A;
- Kockum, I;
- Lernmark, Å;
- Ivarsson, S-A;
- Lernmark, A
Publication type:
journal article
Comparison of radioimmunoprecipitation with luciferase immunoprecipitation for autoantibodies to GAD65 and IA-2beta.
Published in:
2010
By:
- Burbelo PD;
- Hirai H;
- Issa AT;
- Kingman A;
- Lernmark A;
- Ivarsson SA;
- Notkins AL;
- Iadarola MJ;
- Burbelo, Peter D;
- Hirai, Hiroki;
- Issa, Alexandra T;
- Kingman, Albert;
- Lernmark, Ake;
- Ivarsson, Sten-A;
- Notkins, Abner L;
- Iadarola, Michael J
Publication type:
journal article
Metabolomics Profiling of Patients With A-β+ Ketosis-Prone Diabetes During Diabetic Ketoacidosis.
Published in:
2021
By:
- Jahoor, Farook;
- Hsu, Jean W.;
- Mehta, Paras B.;
- Keene, Kelly R.;
- Gaba, Ruchi;
- Mulukutla, Surya Narayan;
- Caducoy, Eunice;
- Peacock, W. Frank;
- Patel, Sanjeet G.;
- Bennet, Rasmus;
- Lernmark, Ake;
- Balasubramanyam, Ashok;
- Rasmus, Bennet;
- Ake, Lernmark
Publication type:
journal article
Progression to type 1 diabetes in the DPT-1 and TN07 clinical trials is critically associated with specific residues in HLA-DQA1-B1 heterodimers.
Published in:
Diabetologia, 2024, v. 67, n. 11, p. 2481, doi. 10.1007/s00125-024-06274-6
By:
- Zhao, Lue Ping;
- Papadopoulos, George K.;
- Skyler, Jay S.;
- Pugliese, Alberto;
- Parikh, Hemang M.;
- Kwok, William W.;
- Lybrand, Terry P.;
- Bondinas, George P.;
- Moustakas, Antonis K.;
- Wang, Ruihan;
- Pyo, Chul-Woo;
- Nelson, Wyatt C.;
- Geraghty, Daniel E.;
- Lernmark, Åke
Publication type:
Article
Biomarker discovery study design for type 1 diabetes in The Environmental Determinants of Diabetes in the Young (TEDDY) study.
Published in:
Diabetes/Metabolism Research & Reviews, 2014, v. 30, n. 5, p. 424, doi. 10.1002/dmrr.2510
By:
- Lee, Hye‐Seung;
- Burkhardt, Brant R.;
- McLeod, Wendy;
- Smith, Susan;
- Eberhard, Chris;
- Lynch, Kristian;
- Hadley, David;
- Rewers, Marian;
- Simell, Olli;
- She, Jin‐Xiong;
- Hagopian, Bill;
- Lernmark, Ake;
- Akolkar, Beena;
- Ziegler, Anette G.;
- Krischer, Jeffrey P.
Publication type:
Article
Methods, quality control and specimen management in an international multicentre investigation of type 1 diabetes: TEDDY.
Published in:
Diabetes/Metabolism Research & Reviews, 2013, v. 29, n. 7, p. 557, doi. 10.1002/dmrr.2427
By:
- Vehik, Kendra;
- Fiske, Steven W.;
- Logan, Chad A.;
- Agardh, Daniel;
- Cilio, Corrado M.;
- Hagopian, William;
- Simell, Olli;
- Roivainen, Merja;
- She, Jin‐Xiong;
- Briese, Thomas;
- Oikarinen, Sami;
- Hyoty, Heikki;
- Ziegler, Anette‐G.;
- Rewers, Marian;
- Lernmark, Ake;
- Akolkar, Beena;
- Krischer, Jeffrey P.;
- Burkhardt, Brant R.
Publication type:
Article
Residual beta cell function at diagnosis of type 1 diabetes in children and adolescents varies with gender and season.
Published in:
Diabetes/Metabolism Research & Reviews, 2013, v. 29, n. 1, p. 85, doi. 10.1002/dmrr.2365
By:
- Samuelsson, U.;
- Lindblad, B.;
- Carlsson, A.;
- Forsander, G.;
- Ivarsson, S.;
- Kockum, I.;
- Lernmark, Å.;
- Marcus, C.;
- Ludvigsson, J.
Publication type:
Article
Glutamic acid decarboxylase antibodies (GADA) is the most important factor for prediction of insulin therapy within 3 years in young adult diabetic patients not classified as Type 1 diabetes on clinical grounds.
Published in:
2000
By:
- Törn, Carina;
- Landin-Olsson, Mona;
- Östman, Jan;
- Scherstén, Bengt;
- Arnqvist, Hans;
- Blohmé, Göran;
- Björk, Elisabeth;
- Bolinder, Jan;
- Eriksson, Jan;
- Littorin, Bengt;
- Nyström, Lennarth;
- Sundkvist, Göran;
- Lernmark, Åke;
- Törn, C;
- Landin-Olsson, M;
- Ostman, J;
- Scherstén, B;
- Arnqvist, H;
- Blohmé, G;
- Björk, E
Publication type:
journal article
GAD65 vaccination: 5 years of follow-up in a randomised dose-escalating study in adult-onset autoimmune diabetes.
Published in:
Diabetologia, 2009, v. 52, n. 7, p. 1363, doi. 10.1007/s00125-009-1371-2
By:
- Agardh, C.-D.;
- Lynch, K.;
- Palmér, M.;
- Link, K.;
- Lernmark, Å.
Publication type:
Article
Children developing type 1 diabetes before 6 years of age have increased linear growth independent of HLA genotypes.
Published in:
Diabetologia, 2008, v. 51, n. 9, p. 1623, doi. 10.1007/s00125-008-1074-0
By:
- Larsson, H.;
- Hansson, G.;
- Carlsson, A.;
- Cederwall, E.;
- Jonsson, B.;
- Jönsson, B.;
- Larsson, K.;
- Lynch, K.;
- Neiderud, J.;
- Lernmark, Å.;
- Ivarsson, S.-A.
Publication type:
Article
The BioBreeding rat diabetes model is infected with Ljungan virus.
Published in:
2007
By:
- Niklasson, B.;
- Hultman, T.;
- Kallies, R.;
- Niedrig, M.;
- Nilsson, R.;
- Berggren, P.-O.;
- Juntti-Berggren, L.;
- Efendic, S.;
- Lernmark, A.;
- Klitz, W.
Publication type:
Correction Notice
The BioBreeding rat diabetes model is infected with Ljungan virus.
Published in:
2007
By:
- Niklasson, Bo;
- Hultman, T.;
- Kallies, R.;
- Niedrig, M.;
- Nilsson, R.;
- Berggren, P.-O.;
- Juntti-Berggren, L.;
- Efendic, S.;
- Lernmark, A.;
- Klitz, W.
Publication type:
Letter
A variant in the transcription factor 7-like 2 ( TCF7L2) gene is associated with an increased risk of gestational diabetes mellitus.
Published in:
Diabetologia, 2007, v. 50, n. 5, p. 972, doi. 10.1007/s00125-007-0623-2
By:
- Shaat, N.;
- Lernmark, Å.;
- Karlsson, E.;
- Ivarsson, S.;
- Parikh, H.;
- Berntorp, K.;
- Groop, L.
Publication type:
Article
Prenatal viral exposure followed by adult stress produces glucose intolerance in a mouse model.
Published in:
Diabetologia, 2006, v. 49, n. 9, p. 2192, doi. 10.1007/s00125-006-0339-8
By:
- Niklasson, B.;
- Samsioe, A.;
- Blixt, M.;
- Sandler, S.;
- Sjöholm, Å.;
- Lagerquist, E.;
- Lernmark, Å.;
- Klitz, W.
Publication type:
Article
Common variants in MODY genes increase the risk of gestational diabetes mellitus.
Published in:
2006
By:
- Shaat, N.;
- Karlsson, E.;
- Lernmark, Å.;
- Ivarsson, S.;
- Lynch, K.;
- Parikh, H.;
- Almgren, P.;
- Berntorp, K.;
- Groop, L.
Publication type:
Correction Notice

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