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- Title
Chloramphenicol decreases brain glucose utilization and modifies the sleep–wake cycle architecture in rats.
- Authors
Moulin-Sallanon, Marcelle; Millet, Philippe; Rousset, Colette; Zimmer, Luc; Debilly, Gabriel; Petit, Jean-Marie; Cespuglio, Raymond; Magistretti, Pierre; Ibáñez, Vicente
- Abstract
We studied the effects of chloramphenicol on brain glucose utilization and sleep–wake cycles in rat. After slightly anaesthetized animals were injected with[18F]fluoro-2-deoxy-d-glucose, we acquired time–concentration curves from three radiosensitiveβ microprobes inserted into the right and left frontal cortices and the cerebellum, and applied a three-compartment model to calculate the cerebral metabolic rates for glucose. The sleep–wake cycle architecture was analysed in anaesthetic-free rats by recording electroencephalographic and electromyographic signals. Although chloramphenicol is a well-established inhibitor of oxidative phosphorylation, no compensatory increase in glucose utilization was detected in frontal cortex. Instead, chloramphenicol induced a significant 23% decrease in the regional cerebral metabolic rate for glucose. Such a metabolic response indicates a potential mismatch between energy supply and neuronal activity induced by chloramphenicol administration. Regarding sleep–wake states, chloramphenicol treatment was followed by a 64% increase in waking, a 20% decrease in slow-wave sleep, and a marked 59% loss in paradoxical sleep. Spectral analysis of the electroencephalogram indicates that chloramphenicol induces long-lasting modifications of delta-band power during slow-wave sleep.
- Subjects
CHLORAMPHENICOL; ANTIBACTERIAL agents; GLUCOSE; SLEEP-wake cycle; RAPID eye movement sleep
- Publication
Journal of Neurochemistry, 2005, Vol 93, Issue 6, p1623
- ISSN
0022-3042
- Publication type
Article
- DOI
10.1111/j.1471-4159.2005.03167.x