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- Title
Antidiabetic potential of Balanites Aegyptiaca kernel, flesh and their combination against streptozotocin-induced hyperglycemia in male rats.
- Authors
Al-Thobaiti, Saed A.; Abu Zeid, Isam M.
- Abstract
Purpose: To investigate the antidiabetic effect of Balanites aegyptiaca fruit kernel, flesh and their mixture on streptozocin (STZ)-induced diabetes in male rats. Methods: Six-week-old male Wistar rats were divided into nine groups: (1) control; (2) kernel; (3) flesh; (4) kernel + flesh; (5) STZ; (6) STZ + kernel; (7) STZ + flesh; (8) STZ + (kernel + flesh) and (9) STZ + metformin. Body weight changes, fasting blood glucose and serum insulin were assessed. Haematoxylin and Eosin (H & E) stained pancreas sections were examined microscopically for the number and status of β cells. Results: Administration of Balanites aegyptiaca kernel, flesh and their mixture significantly increased rat body weight compared to STZ-treated rats. In addition, the hypoglycemic effect of kernel, flesh and their mixture was noticed. In STZ-treated rats, administration of Balanites aegyptiaca kernel and kernel + flesh mixture significantly increased serum insulin (p < 0.05). Histopathological examination revealed a marked increase in the islets cell population with cellular activation, with superior effect in STZ + kernel group and STZ + (kernel + flesh) group. Conclusion: Balanites aegyptiaca showed a hypoglycemic effect which is comparable to metformin action. Further studies are required to determine its suitability as an anti-diabetic agent in humans
- Subjects
HYPOGLYCEMIC agents; BALANITES aegyptiacus; STREPTOZOTOCIN; HYPERGLYCEMIA; LABORATORY rats
- Publication
Tropical Journal of Pharmaceutical Research, 2019, Vol 18, Issue 2, p263
- ISSN
1596-5996
- Publication type
Article
- DOI
10.4314/tjpr.v18i2.7