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- Title
Neural Global Pattern Similarity Underlies True and False Memories.
- Authors
Zhifang Ye; Bi Zhu; Liping Zhuang; Zhonglin Lu; Chuansheng Chen; Gui Xue
- Abstract
The neural processes giving rise to human memory strength signals remain poorly understood. Inspired by formal computational models that posit a central role of global matching in memory strength, we tested a novel hypothesis that the strengths of both true and false memories arise from the global similarity of an item's neural activation pattern during retrieval to that of all the studied items during encoding (i.e., the encoding-retrieval neural global pattern similarity [ER-nGPS]). We revealed multiple ER-nGPS signals that carried distinct information and contributed differentially to true and false memories: Whereas the ER-nGPS in the parietal regions reflected semantic similarity and was scaled with the recognition strengths of both true and false memories, ER-nGPS in the visual cortex contributed solely to true memory. Moreover, ER-nGPS differences between the parietal and visual cortices were correlated with frontal monitoring processes. By combining computational and neuroimaging approaches, our results advance a mechanistic understanding of memory strength in recognition.
- Subjects
FALSE memory syndrome; VISUAL cortex physiology; MAGNETIC resonance imaging of the brain; MEMORY; MATRIX metalloproteinases; COMPUTATIONAL neuroscience
- Publication
Journal of Neuroscience, 2016, Vol 36, Issue 25, p6792
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.0425-16.2016