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- Title
Propagating Neural Source Revealed by Doppler Shift of Population Spiking Frequency.
- Authors
Mingming Zhang; Shivacharan, Rajat S.; Chia-Chu Chiang; Gonzalez-Reyes, Luis E.; Durand, Dominique M.
- Abstract
Electrical activity in the brain during normal and abnormal function is associated with propagating waves of various speeds and directions. It is unclear how both fast and slow traveling waves with sometime opposite directions can coexist in the same neural tissue. By recording population spikes simultaneously throughout the unfolded rodent hippocampus with a penetrating microelectrode array, we have shown that fast and slow waves are causally related, so a slowly moving neural source generates fast-propagating waves at ~0.12 m/s. The source of the fast population spikes is limited in space and moving at -0.016 m/s based on both direct and Doppler measurements among 36 different spiking trains among eight different hippocampi. The fact that the source is itself moving can account for the surprising direction reversal of the wave. Therefore, these results indicate that a small neural focus can move and that this phenomenon could explain the apparent wave reflection at tissue edges or multiple foci observed at different locations in neural tissue.
- Subjects
ELECTRONIC behavior control; DOPPLER effect; BRAIN waves; NERVE tissue; HIPPOCAMPUS (Brain); MICROELECTRODES; LABORATORY rats
- Publication
Journal of Neuroscience, 2016, Vol 36, Issue 12, p3495
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.3525-15.2016