We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The Role of Tissue Factor in Thrombosis and Hemostasis.
- Authors
Malý, M. A.; Tomašov, P.; Hájek, P.; Blaško, P.; Hrachovinová, I.; Salaj, P.; Veselka, J.
- Abstract
The tissue factor (TF) is one of the most important regulators of arterial thrombosis. Because arterial thrombosis is the pathophysiologic background of acute coronary syndrome, the possible impact of blocking the arterial thrombosis on its onset is a challenging problem. The investigations of TF brought a new concept of "cell-based coagulation model" which highlighted the question of blood-borne TF as a source of TF in circulating blood. In this review we summarize essential information on the pathophysiology, molecular structure, expression and distribution of TF and we propose a novel concept of blood-borne TF, suggesting the possibilities of inhibition of the coagulation cascade with newly synthetized drugs.
- Subjects
THROMBOPLASTIN; THROMBOSIS; HEMOSTASIS; CORONARY disease; BLOOD coagulation factors
- Publication
Physiological Research, 2007, Vol 56, Issue 6, p685
- ISSN
0862-8408
- Publication type
Article
- DOI
10.33549/physiolres.931054