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- Title
Fetal loss and maternal serum levels of 2,2',4,4',5,5'-hexachlorbiphenyl (CB-153) and 1,1'-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) exposure: a cohort study in Greenland and two European populations.
- Authors
Toft, Gunnar; Thulstrup, Ane M.; Jönsson, Bo A.; Pedersen, Henning S.; Ludwicki, Jan K.; Zvezday, Valentyna; Bonde, Jens P.
- Abstract
Background: In the present study, the aim is to examine the risk of fetal loss related to environmental 2,2',4,4',5,5'- hexachlorobiphenyl (CB-153) or 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) exposure. Methods: We related LC/MS/MS measurements of CB-153 and p,p'-DDE in serum samples to interview-data on previous fetal loss in populations of pregnant women from Poland, Ukraine and Greenland. Results: In total, 1710 women were interviewed, and 678 of these had at least one previous pregnancy. The risk of ever experiencing a fetal loss increased at higher levels of CB-153 and p,p'-DDE exposure, with an adjusted odds ratio (OR) of 2.4; confidence interval (CI) (1.1-5.5) for CB-153>200 ng/g lipid compared to 0-25 ng CB-153/g lipid and OR of 2.5 CI (0.9-6.6) for p,p'-DDE>1500 ng/g lipid compared to 0-250 ng DDE/g lipid. However, no clear dose response associations were observed. The results further suggest that high level of organochlorine serum concentrations may be related to repeated loss. Conclusions: The risk of fetal loss may increase at higher levels of CB-153 and p,p'-DDE exposure, although lack of dose response and inconsistencies between countries did not allow for firm conclusions.
- Subjects
FETAL death; CHLOROPHENYLALANINE; SERUM; INTERVIEWING; PREGNANT women
- Publication
Environmental Health: A Global Access Science Source, 2010, Vol 9, p22
- ISSN
1476-069X
- Publication type
Article
- DOI
10.1186/1476-069X-9-22