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- Title
Clinical relevance of using autofluorescence bronchoscopy and white light bronchoscopy in different types of airway lesions.
- Authors
Zheng Liu; Ye Zhang; Yin-Peng Li; Jiao Ma; Fang Shi; Dong-Fang Zhao; Jian-Min Li; Yan-Zong Zhang; Liu, Zheng; Zhang, Ye; Li, Yin-Peng; Ma, Jiao; Shi, Fang; Zhao, Dong-Fang; Li, Jian-Min; Zhang, Yan-Zong
- Abstract
<bold>Objectives: </bold>The aim of this study was to evaluate the sensitivity and specificity of autofluorescence bronchoscopy (AFB) according to the macroscopic appearance of airway lesions under white light bronchoscopy (WLB). <bold>Materials and Methods: </bold>The bronchoscopic findings of 708 patients, who were pathologically and clinically diagnosed with airway lesions and underwent both WLB and AFB, were analyzed. <bold>Results: </bold>We recruited 708 patients for this study, of which 336 (47.5%) had benign lesions; 300 and 254 benign lesions were detected by AFB (specificity, 89.3%) and WLB (specificity, 75.6%), respectively. In 372 (52.5%) patients with bronchiogenic carcinoma, 356 and 235 lesions were identified by AFB (sensitivity, 95.7%) and WLB (sensitivity, 63.2%), respectively. The sensitivity and specificity of AFB for diagnosing lung cancer were higher than those of WLB (P < 0.05). Moreover, AFB showed high sensitivity for detecting lung cancer in cases in which WLB revealed hyperplasia, infiltration, and stenosis (P < 0.05). <bold>Conclusions: </bold>AFB combined with WLB could effectively improve the diagnosis of airway lesions.
- Subjects
LUNG cancer diagnosis; BIOFLUORESCENCE; BRONCHOSCOPY; SENSITIVITY (Personality trait); LUNG cancer patients; ADENOCARCINOMA; DIAGNOSTIC imaging; LUNGS; LUNG tumors; TUMORS
- Publication
Journal of Cancer Research & Therapeutics, 2016, Vol 12, Issue 1, p69
- ISSN
0973-1482
- Publication type
journal article
- DOI
10.4103/0973-1482.147731