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- Title
Ouabain as a Mammalian Hormone.
- Authors
SCHONER, WILHELM; BAUER, NATALI; MÜLLER-EHMSEN, JOCHEN; KRÄMER, ULRIKE; HAMBARCHIAN, NJDE; SCHWINGER, ROBERT; MOELLER, HANS; KOST, HOLGER; WEITKAMP, CHRISTINE; SCHWEITZER, THOMAS; KIRCH, ULRIKE; NEU, HORST; GRÜNBAUM, ERNST-GÜNTHER
- Abstract
A bstract: Endogenous ouabain changes rapidly in humans and dogs upon physical exercise and is under the control of epinephrine and angiotensin II. Hence, the steroid acts as a rapidly acting hormone. A search for a specific binding globulin for cardiac glycosides in bovine plasma resulted in the identification of the d allotype of the μ chain of IgM whose hydrophobic surfaces interact with cardiotonic steroids and cholesterol. Such IgM complexes might be involved in the hepatic elimination of cardiotonic steroids. Thus, differences in the signaling cascade starting at Na+,K+-ATPase must explain any differences in the action of ouabain and digoxin in the genesis of arterial hypertension.
- Publication
Annals of the New York Academy of Sciences, 2003, Vol 986, Issue 1, p678
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1111/j.1749-6632.2003.tb07282.x