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- Title
Conjugates with an Antimicrobial Effect Based on New Derivatives of Mercaptobenzoxazole Esterified onto Poly(maleic anhydride- alt-vinyl acetate).
- Authors
Aparaschivei, Radita; Şunel, Valeriu; Popa, Marcel; Desbrieres, Jacques
- Abstract
New compounds with based on hydroxy-amino derivatives of benzoxazolyl-2-mercaptoformic acid, benzoxazolyl-2-mercaptoacetic acid, and chloracetyl-2-mercaptobenzoxazole have been synthesized. The chemical bonding of these compounds to poly(maleic anhydride- alt-vinyl acetate), through , leads in obtaining conjugates of polymer compound type, tests indicating a sustained release of the active chemical, with time (between 5 and 6 h). Reaction products were characterized through elemental and spectral analysis (FTIR and 1H NMR). Toxicology and tests recommend compounds with small molecule, as well as their conjugates as therapeutical candidates (antimicrobial inhibitors) for pharmacological application.
- Subjects
BENZENE compound synthesis; FORMIC acid; OXAZOLES; ACETATES; POLYMER research
- Publication
Journal of Heterocyclic Chemistry, 2014, Vol 51, Issue 4, p1124
- ISSN
0022-152X
- Publication type
Article
- DOI
10.1002/jhet.1814