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- Title
Polycyclic N-Heterocyclic Compounds. Part 82: Synthesis and Evaluation of Anti-Platelet Aggregation Activity of 2,4-Disubstituted 5,6-Dihydro[1]benzothiepino[5,4- d]pyrimidine and Related Compounds.
- Authors
Okuda, Kensuke; Hirota, Takashi; Sasaki, Kenji
- Abstract
We have synthesized a large number of tricyclic 2-substituted 4-alkylamino-5,6-dihydro[1]benzothiepino[5,4- d]pyrimidines as part of our research to develop new effective anti-platelet drugs. A variety of alkyl and aryl groups were used as substituents at the 2-position. Evaluation of the effects of the newly synthesized compounds on collagen-induced platelet aggregation revealed several promising anti-platelet candidates with potencies superior to aspirin.
- Subjects
BENZENE compound synthesis; ALKYL compounds; PLATELET aggregation inhibitors; COLLAGEN; ASPIRIN
- Publication
Journal of Heterocyclic Chemistry, 2014, Vol 51, Issue 4, p911
- ISSN
0022-152X
- Publication type
Article
- DOI
10.1002/jhet.1741