We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Dopamine Depletion Hypothesis of Cocaine Dependence: A Test.
- Authors
Gill, K.; Gillespie, H. K.; Hollister, L. E.; Davis, C. M.; Peabody, C. A.
- Abstract
Measurements of plasma homovanillic acid (HVA), plasma 3-methoxy-4-hydroxyphenylglycol (MHPG). serum prolactin and Hamilton Depression Rating Scale (HDRS) scores were made in 21 cocaine-dependent patients seeking inpatient treatment. These measurements were obtained within 1-3 days of the last dose of cocaine and were repealed after 10-20 days of abstinence from cocaine. Abnormal values on any of the biochemical measurements were unusual and showed no convincing evidence of dopamine or norepinephrine depletion. Ten patients had significant HDRS scores on admission which decreased by 50% or more during hospitalization without specific treatment. The controversy over whether chronic exposure to cocaine depletes dopamine remains unsettled. However, it is more likely that down-regulation of postsynaptic dopamine receptors is the major consequence of such exposure.
- Subjects
DOPAMINE; DOPAMINE receptors; COCAINE; NEUROTRANSMITTER receptors; CELL receptors; CATECHOLAMINES
- Publication
Human Psychopharmacology: Clinical & Experimental, 1991, Vol 6, Issue 1, p25
- ISSN
0885-6222
- Publication type
Article
- DOI
10.1002/hup.470060105