We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
New dinuclear cobalt(II) complexes as "self‐activating" chemical nuclease and inhibitor of tumor cell invasion: High selective cytotoxicity against NCI‐H460 cells.
- Authors
Zhang, Yong‐Po; He, Qing; Zhao, Yan‐Yang; Qiao, Pei‐Pei; Tian, Yue‐Wei; Gao, Chun‐Yan; Tian, Jin‐Lei; Du, Wei‐Jun; Yan, Shi‐Ping
- Abstract
Three new dinuclear Co(II) complexes [Co2(L1)2Cl2](PF6)2 (1), [Co2L2(OAc)2(CH3OH)4](ClO4)2 (2), and [Co2L3(OAc)2(CH3OH)4](ClO4)2 (3) were synthesized and structurally determined by X‐ray single‐crystal diffraction analysis as well as IR, elemental analysis, and mass spectrometry. All complexes exhibit efficiently self‐activated cleavage activity with hydrolytic mechanism, which was accurately proved by addition of regular radical scavengers, anaerobic cleavage experiment, and 2‐thiobarbituric acid reaction. Complex 1 exhibited higher selective cytotoxicity against tumor cells than normal cells, which is significantly better than that of cisplatin. Hoechst 33342 staining, intracellular ROS generation and mitochondrial membrane potential were conducted to assess the apoptosis‐inducing activity of 1. The effect of complex 1 on cell invasion was observed by Transwell assay and angiogenesis experiment, and the results demonstrated that 1 could inhibit the cell invasion and angiogenesis.
- Subjects
CHEMICAL inhibitors; MITOCHONDRIAL membranes; COBALT; MEMBRANE potential; MASS spectrometry; ELEMENTAL analysis
- Publication
Applied Organometallic Chemistry, 2023, Vol 37, Issue 5, p1
- ISSN
0268-2605
- Publication type
Article
- DOI
10.1002/aoc.7074