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- Title
One‐pot synthesis of POM‐CaO<sub>2</sub>@ZIF‐8 nanoparticles with self‐supply of H<sub>2</sub>O<sub>2</sub> for electrically enhanced chemodynamic therapy.
- Authors
Sun, Tiedong; Yue, Zhengya; Song, Yan; Ni, Jiatong; Wang, Wenxin; Zhao, Junge; Li, Jialun; Sun, Yuan; Li, Bin
- Abstract
Chemodynamic therapy (CDT) is a highly effective clinical treatment strategy based on the Fenton or Fenton‐like responses. However, its efficacy has been greatly limited by the complex tumor microenvironment, TME, such as the low levels of H2O2 and the overexpression of the glutathione (GSH). Polyoxometalates (POMs) are compounds that consist of anionic transition metal oxide clusters, such as tungsten (W) and molybdenum (Mo), and notably, these compounds have excellent redox properties in biological systems that can be utilized therapeutically. Therefore, POM‐CaO2@ZIF‐8 nanoparticles (NPs) have been synthesized and used as a mediator to develop an electrically enhanced CDT strategy. It is hoped that the simultaneous modulation of endogenous (the H2O2 generated by CaO2 NPs and GSH depletion by POM) and exogenous (Electric, E) stimulation enhanced Fenton‐like responses will lead to better therapeutic results. Such a treatment strategy has shown excellent tumor cell killing effects in both in vitro and in vivo studies.
- Subjects
METAL clusters; TRANSITION metal oxides; MOLYBDENUM; NANOPARTICLES; POLYOXOMETALATES; BIOLOGICAL systems; TUMOR microenvironment
- Publication
Applied Organometallic Chemistry, 2022, Vol 36, Issue 12, p1
- ISSN
0268-2605
- Publication type
Article
- DOI
10.1002/aoc.6888