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- Title
Synthesis and applications in Henry reactions of novel chiral thiazoline tridentate ligands.
- Authors
Shi, Ye; Li, Yang; Sun, Jingbo; Lai, Qi; Wei, Chiyu; Gong, Zhiyong; Gu, Qiang; Song, Zhiguang
- Abstract
Several novel chiral tridentate ligands containing thiazoline were efficiently synthesized from commercially available l=cysteine in high yield. These ligands were subsequently applied to the asymmetric of nitromethane and various aldehydes. It was found that the structures of the thiazoline ligands had a significant influence on the . It was shown that the optimal catalyst for this reaction was a ligand complexed with CuCl, which was formed from chiral thiazoline with chiral aminoalcohol. At −20°C, with 10 mol% of this ligand, a product with ( S)-configuration was isolated in 93% yield and 98% enantiomeric excess. Copyright © 2015 John Wiley & Sons, Ltd.
- Subjects
NITROALDOL reactions; ENANTIOSELECTIVE catalysis; THIAZOLINES; LIGANDS (Chemistry); NITROMETHANE
- Publication
Applied Organometallic Chemistry, 2015, Vol 29, Issue 10, p661
- ISSN
0268-2605
- Publication type
Article
- DOI
10.1002/aoc.3347