We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Ultrahigh b-values MRI in normal human prostate: Initial research on reproducibility and age-related differences.
- Authors
Shi, Changzheng; Zhang, Dong; Xiao, Zeyu; Wang, Li; Ma, Rong; Chen, Hanwei; Luo, Liangping
- Abstract
<bold>Purpose: </bold>To investigate the reproducibility of diffusion-weighted imaging (DWI) with ultrahigh b-values, and analyze the age-related differences in normal prostates.<bold>Materials and Methods: </bold>In all, 67 healthy participants were divided into three age groups (group A, 15-30 years; group B, 31-50 years; group C, ≥51 years), and underwent DWI scanning twice with 15 b-factors from 0 to 3000 at 3.0T. Triexponential fits were applied to calculate the molecular diffusion coefficient (D), the pseudo-diffusion coefficient (D*), the ultrahigh apparent diffusion coefficient (ADCuh ), and perfusion fraction (f). The interobserver and short-term interscan reproducibility were evaluated, and the change in these parameters with age were assessed.<bold>Results: </bold>The D, ADCuh , and f values presented good to excellent reproducibility. With increasing age, a trend of increasing D values was observed, with significant difference in both peripheral zone (PZ, P = 0.01) and central gland (CG, P = 0.01) of normal prostate tissue. The f value increased in the CG beginning at 50 years of age while the ADCuh value decreased in the PZ after 50 years of age; all of them showed significant differences between groups A and C and groups B and C (P = 0.01/0.01).<bold>Conclusion: </bold>The D, ADCuh , and f values have good to excellent reproducibility in the normal prostate, and these values change with age. The ultrahigh b-values magnetic resonance imaging (MRI) can provide additional information (ADCuh ), which is different from the IVIM (intravoxel incoherent motion)-derived parameters.<bold>Level Of Evidence: </bold>1 Technical Efficacy: Stage 2 J. MAGN. RESON. IMAGING 2017;46:801-812.
- Subjects
PROSTATE; AGE distribution; MAGNETIC resonance imaging; REFERENCE values; RESEARCH evaluation; ANATOMY
- Publication
Journal of Magnetic Resonance Imaging, 2017, Vol 46, Issue 3, p801
- ISSN
1053-1807
- Publication type
journal article
- DOI
10.1002/jmri.25629