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- Title
Initial study on in vivo conductivity mapping of breast cancer using MRI.
- Authors
Shin, Jaewook; Kim, Min Jung; Lee, Joonsung; Nam, Yoonho; Kim, Min‐oh; Choi, Narae; Kim, Sooyeon; Kim, Dong‐Hyun
- Abstract
<bold>Purpose: </bold>To develop and apply a method to measure in vivo electrical conductivity values using magnetic resonance imaging (MRI) in subjects with breast cancer. <bold>Materials and Methods: </bold>A recently developed technique named MREPT (MR electrical properties tomography) together with a novel coil combination process was used to quantify the conductivity values. The overall technique was validated using a phantom study. In addition, 90 subjects were imaged (50 subjects with previously biopsy-confirmed breast tumor and 40 normal subjects), which was approved by our institutional review board (IRB). A routine clinical protocol, specifically a T2 -weighted FSE (fast spin echo) imaging data, was used for reconstruction of conductivity. <bold>Results: </bold>By employing the coil combination, the relative error in the conductivity map was reduced from ~70% to 10%. The average conductivity values in breast cancers regions (0.89 ± 0.33S/m) was higher compared to parenchymal tissue (0.43 S/m, P < 0.0001) and fat (0.07 S/m, P < 0.00005) regions. Malignant cases (0.89 S/m, n = 30) showed increased conductivity compared to benign cases (0.56 S/m, n = 5) (P < 0.05). In addition, invasive cancers (0.96 S/m) showed higher mean conductivity compared to in situ cancers (0.57 S/m) (P < 0.0005). <bold>Conclusion: </bold>This study shows that conductivity mapping of breast cancers is feasible using a noninvasive in vivo MREPT technique combined with a coil combination process. The method may provide a tool in the MR diagnosis of breast cancer.
- Publication
Journal of Magnetic Resonance Imaging, 2015, Vol 42, Issue 2, p371
- ISSN
1053-1807
- Publication type
journal article
- DOI
10.1002/jmri.24803