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- Title
Fatty-Acid-Rich Agave angustifolia Fraction Shows Antiarthritic and Immunomodulatory Effect.
- Authors
Jiménez-Ferrer, Enrique; Vargas-Villa, Gabriela; Martínez-Hernández, Gabriela Belen; González-Cortazar, Manases; Zamilpa, Alejandro; García-Aguilar, Maribel Patricia; Arenas-Ocampo, Martha Lucía; Herrera-Ruiz, Maribel
- Abstract
Agave angustifolia is a xerophytic species widely used in Mexico as an ingredient in sweet food and fermented beverages; it is also used in traditional medicine to treat wound pain and rheumatic damage, and as a remedy for psoriasis. Among the various A. angustifolia extracts and extract fractions that have been evaluated for their anti-inflammatory effects, the acetonic extract (AaAc) and its acetonic (F-Ac) and methanolic (F-MeOH) fractions were the most active in a xylene-induced ear edema model in mice, when orally administered. Four fractions resulting from chemically resolving F-Ac (F1–F4) were locally applied to mice with phorbol 12-myristate 13-acetate (TPA)-induced ear inflammation; F1 inhibited inflammation by 70% and was further evaluated in a carrageenan-induced mono-arthritis model. When administered at doses of 12.5, 25, and 50 mg/kg, F1 reduced articular edema and the spleen index. In addition, it modulated spleen and joint cytokine levels and decreased pain. According to a GC–MS analysis, the main components of F1 are fatty-acid derivatives: palmitic acid methyl ester, palmitic acid ethyl ester, octadecenoic acid methyl ester, linoleic acid ethyl ester, and oleic acid ethyl ester.
- Subjects
MEXICO; OLEIC acid; AGAVES; SWEETNESS (Taste); ETHYL esters; PALMITIC acid; METHYL formate
- Publication
Molecules, 2022, Vol 27, Issue 21, p7204
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules27217204